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抗生素干预加剧了SD大鼠的氧化应激和炎症反应,而SD大鼠在hypobaric hypoxia暴露下

Yang Liao¹, Zheng Chen¹, Yingkui Yang¹

¹College of Animal Husbandry and Veterinary Sciences, Qinghai University, Xining, 810016, China.

Free radical biology & medicine

|October 8, 2023

概括

在暴露于高海拔地区的老鼠中,抗生素治疗改变了肠道细菌,增加了炎症. 像Lactobacillus这样的有益细菌可能会改善适应低氧环境.

科学领域:

微生物学微生物学
环境生理学环境生理学
动物科学动物科学

背景情况:

肠道微生物群对于宿主健康至关重要,尤其是在极端条件下.
在低性缺氧期间肠道微生物群调节的机制尚未完全理解.

研究的目的:

为了研究抗生素诱导的肠道失生症对暴露于低性缺氧的SD大鼠的影响.
确定影响适应高海拔环境的肠道微生物群相关机制.

主要方法:

对抗生素治疗和未治疗的SD老鼠在一个模拟的6000米高度室中进行了30天的比较.
使用16S rRNA测序和非向代谢学分析血液,便和肺组织.

主要成果:

抗生素治疗导致中性粒细胞和单细胞的增加,硫酸盐减少细菌的丰富,谷氨的减少,以及脂 (LPA,LPS,LPC) 的积累.
这些变化与增加的氧化应激和炎症相关.
富含Prevotellaceae和乳酸菌与减少氧化应激和炎症有关.

结论:

肠道功能障碍症会加剧氧化应激和炎症,而在低性缺氧中则会加剧.
促进像乳酸菌这样的有益细菌可能会增强动物适应高海拔条件.

关键词:

适应能力适应能力抗生素 (ABX) 尾酒是一种抗生素我们的肠道微生物群.炎症炎症是一种炎症.氧化应激是一种氧化应激.

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