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对原益生菌进行试点研究,以进一步改善移植后已经稳定的移植功能
Wai-Nga Chan1, Dong-Ru Ho1, Yun-Ching Huang1
1Divisions of Urology, Department of Surgery, Chang Gung Medical Foundation, Chiayi City 613, Taiwan.
Transplantation proceedings
|October 8, 2023
概括
益生菌 Lactobacillus plantarum 和 Lactobacillus paracasei (Lm) 可能改善移植接受者的结局. 免疫抑制剂补充与改善功能和降低免疫抑制剂剂量的潜力有关.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 微生物学 微生物学
- 移植 移植 移植 移植
背景情况:
- 接受移植的人往往患有慢性病.
- 之前的研究表明,乳酸菌植物菌和乳酸菌 (Lm) 改善了小鼠的功能.
- 这项研究评估了人类脏移植接受者的Lm.
研究的目的:
- 评估Lm对接受脏移植的接受者的移植功能的影响.
- 研究Lm对免疫抑制药物水平的影响.
- 评估Lm补充剂在这个患者群体中的安全性.
主要方法:
- 24名脏移植接受者的回顾性审查.
- 在12名患者的Lm补充前和后,肌素和估计的淋巴球过率 (eGFR) 的比较.
- 评估免疫抑制药物水平和感染事件.
- 实验室校准使用12名没有Lm的患者.
主要成果:
- 在Lm补充后,肌素水平降低了0.06 mg/dL (P=.02) 和eGFR增加了3.1 mL/min/1.73 m2 (P=.03).
- 在Lm使用和肌素降低 (OR 13.3,P=.01) 之间发现了显著的关联.
- 随着Lm使用,观察到更高的塔克罗利斯和西罗利斯低谷水平的趋势.
结论:
- 补充剂与移植接受者的功能标志物改善有关.
- Lm可能提供一种潜在的降低免疫抑制剂剂量的策略.
- 需要进一步的研究来证实这些发现,并探索最佳的LM使用.
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