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新生牛犊的总和病原体特定血清免疫球蛋白G度,第1部分:风险因素
Lisa Gamsjäger1, Deborah M Haines2, Michel Lévy1
1University of Calgary Faculty of Veterinary Medicine, 11877 85th Street NW, Calgary, AB T3R 1J3, Canada.
Preventive veterinary medicine
|October 8, 2023
概括
牛乳中的母体抗体对于小牛的健康至关重要. 这项研究发现,虽然母乳疫苗接种提高了特定免疫球蛋白G (IgG) 水平,但乳牛奶干预与较低的IgG有关,并且增加了牛犊被动免疫力衰竭的风险.
科学领域:
- 兽医免疫学和群体健康.
- 牛的新生儿学和疾病预防.
背景情况:
- 通过胆乳产生的母体抗体对于保护小牛免受疾病的保护至关重要.
- 影响牛肉小牛总和特异性免疫球蛋白G (IgG) 转移的因素尚不清楚.
- 免疫的被动转移对于新生儿小牛的生存和健康至关重要.
研究的目的:
- 确定影响新生牛肉的总和特定IgG度的风险因素.
- 调查与被动免疫传递失败 (FTPI) 和被动免疫传递不足 (ITPI) 相关的因素.
- 对常见的肠道和呼吸道病原体进行IgG水平的分析:大肠杆菌,BRoV,C. parvum,BVDV,PI-3,BRSV和BHV-1.
主要方法:
- 分析了阿尔伯塔省6个农场420只肉牛 (1-7天大) 的血清样本.
- 辐射免疫扩散测量了总IgG;ELISA量化了病原体特异性IgG.
- 多变量回归模型评估了IgG度和被动免疫状态的母体和小牛的风险因素.
主要成果:
- 5%的小牛患有FTPI (<10g/L IgG),而18%的小牛患有ITPI (<24g/L IgG).
- 大奶粉干预是低总IgG的重要危险因素,增加了FTPI和ITPI的几率.
- 牛犊的IgG比母牛的IgG高;接种疫苗的母牛对BRoV,BVDV和BHV-1的IgG更高.
结论:
- 虽然干预的目的是帮助,但矛盾的是,与被动免疫转移较差有关.
- 雌雄同性和疫苗接种情况显著影响小牛IgG水平和对特定病原体的保护.
- 牛小牛的运营应该重新评估疫苗接种方案和乳母管理策略,以优化被动免疫力.
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