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在没有糖尿病视网膜病变的情况下,在糖尿病中深层和表面视网膜血管密度变化的OCT-血管学

H Lajmi¹, R Choura¹, A Zahaf¹

¹Ophthalmology Department, FSI Hospital, University of Tunis El Manar, La Marsa, Tunisia.

Journal francais d'ophtalmologie

|October 8, 2023

概括

没有视网膜病变的糖尿病眼睛在表面和深层视网膜网络中显示出血管密度 (VD) 的降低. 光学一致性断层扫描血管图 (OCTA) 可以检测这些早期的微血管变化进行查.

科学领域:

眼科医生眼科眼科
糖尿病学糖尿病学
医疗成像医学成像

背景情况:

糖尿病视网膜病变 (DR) 是导致视力丧失的主要原因.
早期发现微血管变化对于及时干预至关重要.
光学连贯断层扫描血管学 (OCTA) 允许视网膜血管系统的非侵入性可视化.

研究的目的:

为了在没有临床视网膜病变的糖尿病患者和健康对照者之间比较表面和深层毛细血管中的视网膜血管密度 (VD).
为了识别具有显著VD差异的周围区域.
调查影响糖尿病患者眼睛风险因素的风险因素.

主要方法:

涉及没有DR的糖尿病患者和健康对照者的横截面研究.
一个3x3mm区域的OCTA成像,该区域的中心是膜.
在表面和深层毛细血管结合体中对各种周围膜部门的VD进行定量分析.
静脉疾病和风险因素之间的相关性分析,如年龄,肌素清除率和高脂血症.

主要成果:

与对照人群相比,糖尿病患者的眼睛在表面和深层毛细血管的所有部门都表现出明显较低的VD.
表面总体静脉动脉和表面状静脉动脉显示,区分组的曲线下面积 (AUC) 是最高的 (0.992和0.991).
时间部门在表面 (0.990) 和深层 (0.976) 中显示出最高的AUC. 年龄,肌素清除率和超脂血与静脉疾病减少相关.

结论:

在糖尿病患者中,视网膜血管密度在表面和深层都下降,甚至在视网膜病变的临床症状出现之前.
通过检测定量微血管变化,OCTA是早期查糖尿病视网膜病变的有希望的工具.
这些微血管变化可能作为糖尿病并发症的早期生物标志物.

关键词:

血管图通过断层图通过连贯光学.血管密度血管密度糖尿病视网膜病变 - 糖尿病视网膜病变糖尿病视网膜病变 (La rétinopathie diabétique) 是一种糖尿病视网膜病变.光学连贯性断层扫描血管图谱.血管密度血管密度

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