一种基于实验室的新型诺姆图,用于评估急性至慢性肝衰竭患者感染存在的风险
Rui Sun1,2, Wenli Lu2, Wanhua Ren1
1Department of Infectious Diseases, Shandong Provincial Hospital, Shandong University, Jinan, China.
Scientific reports
|October 8, 2023
概括
一个新的WBD模型,结合白细胞计数,血尿素和D-二次体,准确评估急性至慢性肝衰竭 (ACLF) 患者的感染风险. 这种工具有助于临床医生在早期检测和管理,可能降低死亡率.
科学领域:
- 肝病学和传染病研究研究.
- 临床诊断和生物标志物发展
- 关键护理医学 关键护理医学
背景情况:
- 感染是急性至慢性肝衰竭 (ACLF) 死亡的主要驱动因素.
- 准确及时评估感染风险对于有效管理ACLF患者至关重要.
- 目前的诊断方法可能无法充分捕捉ACLF感染风险的复杂性.
研究的目的:
- 开发和验证一种新的诊断模型,用于评估ACLF患者感染存在风险水平.
- 确定ACLF感染的独立预测因素.
- 为实际的临床应用创建视觉名字图.
主要方法:
- 对185名有/没有感染的ACLF患者进行了回顾性分析,检查了人口统计学,临床和实验室参数.
- 开发使用回归分析的诊断模型,包括白细胞 (WBC) 计数,LYM%,血尿素 (BUN) 和D-dimer.
- 使用接收器运行特征曲线 (AUROC) 下面区域和外部队列验证WBD (WBC + BUN + D-二次元) 模型.
主要成果:
- 结合WBC,BUN和D-二次体的WBD模型被确定为一种新的诊断工具.
- 该WBD模型显示出显著的诊断准确性,培训队列的AUROC为0.803,外部验证队列的AUROC为0.885.
- 该模型在不同ACLF病因和阶段显示出高精度,在早期HBV相关ACLF中表现最佳 (AUROC 0.905).
结论:
- WBD模型是可靠的,基于实验室的工具,用于评估ACLF患者的感染风险.
- 这种名图可以帮助临床医生做出及时干预和改善患者结果的决策.
- 在ACLF管理中,WBD模型提供了一种实际的方法来增强感染风险分层.
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