医院人群中SARS-CoV-2感染的严重程度:跨年龄组的临床比较
Chiara Rosazza1, Laura Alagna2, Alessandra Bandera2,3
1Paediatric Cystic Fibrosis Center, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Italian journal of pediatrics
|October 8, 2023
概括
与成人相比,COVID-19 (冠状病毒疾病2019) 在儿童中通常不那么严重. 虽然很少见,但儿童多系统炎症综合征 (MIS-C) 是一种严重的并发症,其危险因素仍然未知.
科学领域:
- 传染性疾病 传染性疾病
- 儿科 儿科 儿科
- 流行病学 流行病学
背景情况:
- 儿童通常会比成年人体验更轻微的COVID-19 (冠状病毒疾病2019).
- 然而,在儿童群体中已经注意到SARS-CoV-2感染的后急性并发症.
- 这项研究调查了COVID-19的结果和儿童与成人的长期并发症.
研究的目的:
- 为了比较COVID-19相关的结果和儿科和成人患者之间的长期并发症.
- 评估不同年龄组的SARS-CoV-2感染的严重程度.
- 为了确定严重的COVID-19结果的相对风险,包括住院和需要补充氧气.
主要方法:
- 一项前性多中心研究 (DECO COVID-19),包括154名RT-PCR确诊的SARS-CoV-2感染者.
- 在三个年龄组中比较COVID-19的严重程度:儿童/青少年 (<18岁),年轻/中年成人 (18-64岁) 和老年人.
- 使用日志-二项式模型来估计严重COVID-19的相对风险 (RR),定义为住院和/或补充氧气需求.
主要成果:
- 与年轻/中年成人相比,儿童/青少年 (84) 的住院风险 (RR:0.49) 和补充氧气需求 (RR:0.12) 较低.
- 老年人患入院的风险更高 (RR: 1.52),需要补充氧气 (RR: 1.46).
- 三名儿童患有多系统炎症综合征 (MIS-C);没有人需要重症监护或报告后急性并发症.
结论:
- 证实COVID-19 (冠状病毒疾病2019) 在儿科患者中不那么严重.
- 儿童多系统炎症综合征 (MIS-C) 是SARS-CoV-2感染的一种罕见但严重的并发症.
- 儿童MIS-C的风险因素目前尚不清楚,需要进一步调查.
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