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卡路里限制诱导的体重减轻的比例作为骨肌肉的比例
Steven B Heymsfield1, Shengping Yang1, Cassidy McCarthy1
1Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana, USA.
Obesity (Silver Spring, Md.)
|October 9, 2023
概括
卡路里限制 (CR) 导致骨肌肉 (SM) 损失,模型预测男性每10公斤体重损失约2-2.5公斤,女性每10公斤体重损失约1-1.5公斤. 这些预测在纵向研究中得到了验证.
科学领域:
- 人类生理学 人类生理学
- 营养科学 营养科学
- 身体组成分析分析.
背景情况:
- 了解卡路里限制 (CR) 期间骨肌肉 (SM) 质量变化对于代谢健康至关重要.
- 以前用于预测CR期间SM损失的模型在不同人群中缺乏验证.
- 没有运动的自愿CR是一种常见的体重管理策略.
研究的目的:
- 在自愿卡路里限制 (CR) 期间开发和验证骨肌肉 (SM) 质量减少的预测模型.
- 在纵向研究中评估这些模型的准确性.
- 提供与体重减轻相对的MS损失的性别特定估计.
主要方法:
- 利用897名健康成年人 (415名男性,482名女性) 的磁共振成像 (MRI) 数据开发了预测模型.
- 在两个纵向队列中验证的模型预测:一个12-14周 (n=74) 和另一个12个月 (n=26).
- 使用MRI测量全身骨肌肉质量.
主要成果:
- 开发的模型预测平均SM损失为0.26 ± 0.013在男性和0.14 ± 0.007在女性每单位的体重损失.
- 纵向验证显示,男性的实际SM损失比例为0.23 ± 0.02/0.20 ± 0.06,女性为0.10 ± 0.02/0.17 ± 0.03.
- 模型的预测与短期和长期研究中观察到的SM损失密切一致.
结论:
- 非老年超重/肥胖的男性和女性经历了随着自愿的CR而显著减少SM质量.
- 估计每10公斤体重减轻的SM损失大约为男性2-2.5公斤,女性1-1.5公斤.
- 在影响SM损失的男性中,年龄和BMI之间的潜在相互作用需要进一步调查.
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