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相关概念视频

Repressible Operon: trp Operon01:21

Repressible Operon: trp Operon

32
The trp operon in Escherichia coli exemplifies a repressible operon. It regulates the synthesis of tryptophan through repressor-mediated transcriptional control and attenuation. This dual regulatory mechanism ensures tryptophan biosynthesis occurs only when needed, conserving cellular resources.Structure of the trp OperonThe trp operon consists of five structural genes (trpE, trpD, trpC, trpB, and trpA) that encode enzymes for tryptophan biosynthesis. These genes are transcribed as a single...
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Co-activators and Co-repressors02:04

Co-activators and Co-repressors

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Gene transcription is regulated by the synergistic action of several proteins that form a complex at a gene regulatory site. This is observed in eukaryotes, where the regulation of gene expression is a complex process. Regulatory proteins in eukaryotes can broadly be classified into two types – regulators that bind directly to specific DNA sequences and co-regulators that associate with regulatory proteins but cannot directly bind to the DNA. These co-regulators are further divided into...
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Transcriptional Regulation: Riboswitches01:23

Transcriptional Regulation: Riboswitches

48
Riboswitches are RNA elements that regulate gene expression by altering their secondary structures in response to specific effector molecules. These elements, located in the leader regions of certain mRNAs, act as transcriptional regulators by toggling between alternative conformations to control downstream gene expression. Riboswitch-mediated regulation is a precise mechanism for modulating biosynthetic pathways, as exemplified by the riboflavin biosynthesis pathway in Bacillus...
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Transducer Mechanism: G Protein–Coupled Receptors01:30

Transducer Mechanism: G Protein–Coupled Receptors

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G Protein–Coupled Receptors (GPCRs) are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to various stimuli. GPCRs regulate critical physiological pathways and are excellent drug targets for treating diseases such as diabetes, cancer, obesity, depression, or Alzheimer's. Nearly 35% of approved drugs implement their therapeutic effects by selectively interacting with specific GPCRs.
GPCRs are also called heptahelical,...
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G Protein-coupled Receptors01:15

G Protein-coupled Receptors

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G Protein-Coupled Receptors or GPCRs are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to sensory stimuli such as light, odors, hormones, cytokines, or neurotransmitters.
GPCRs are also called heptahelical, 7TM, or serpentine receptors, and consist of seven (H1-H7) transmembrane alpha-helices that span the bilayer to form a cylindrical core. The transmembrane helices are connected by three extracellular loops and three...
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RNA Polymerase II Accessory Proteins02:36

RNA Polymerase II Accessory Proteins

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Proteins that regulate transcription can do so either via direct contact with RNA Polymerase or through indirect interactions facilitated by adaptors, mediators, histone-modifying proteins, and nucleosome remodelers. Direct interactions to activate transcription is seen in bacteria as well as in some eukaryotic genes. In these cases, upstream activation sequences are adjacent to the promoters, and the activator proteins interact directly with the transcriptional machinery. For example, in...
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相关实验视频

Updated: Jul 14, 2025

Rapid Development of Cell State Identification Circuits with Poly-Transfection
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Rapid Development of Cell State Identification Circuits with Poly-Transfection

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响应pH的蛋白质转换晶体管

Fei Tao1, Qian Han1, Miaoran Deng1

  • 1Key Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, school of Chemistry and Chemical Engineering, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an, 710119, China.

Angewandte Chemie (International ed. in English)
|October 9, 2023
PubMed
概括
此摘要是机器生成的。

研究人员开发了蛋白质纳米晶体,模仿了类似晶体管的行为,使得更大规模的pH响应组装成为可能. 这一突破为药物输送和生物传感中的先进材料提供了新的可能性.

关键词:
自我凝聚的自我凝聚.晶体管效应 晶体管效应两个阶段的核化.响应pH的交叉连接

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相关实验视频

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Transmembrane Domain Oligomerization Propensity determined by ToxR Assay
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G Protein-selective GPCR Conformations Measured Using FRET Sensors in a Live Cell Suspension Fluorometer Assay
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科学领域:

  • 生物材料科学 生物材料科学
  • 纳米技术纳米技术
  • 聚合物化学 聚合物化学

背景情况:

  • 类似晶体管的响应材料表现出由特定的微环境信号触发的急剧结构转变.
  • 目前的应用主要局限于基于合成聚合物的纳米级组件.
  • 将这种响应性行为扩展到生物聚合物和更大的规模是一个重大挑战.

研究的目的:

  • 从合成聚合物到生物聚合物,发展出类似晶体管的响应性材料系统.
  • 将组装规模从纳米规模扩展到美索/宏观规模.
  • 开发具有核心外结构的蛋白质纳米晶体,用于pH响应的中等尺度组装.

主要方法:

  • 利用两步核化过程创建具有核心外结构的独特蛋白质纳米晶体.
  • 研究的pH响应的中等尺度组件,由粒子间β-sheet链接器形成驱动.
  • 具有特征的超敏感交叉连接行为,包括自我协,超快速凝和胀反应.

主要成果:

  • 成功开发出蛋白质纳米晶体,表现出类似晶体管的pH响应的中等尺度组件.
  • 证明了超敏感的交叉链接,包括在水/水界面的自我协和几秒钟内凝结.
  • 观察到超敏感的胀,以检测极低度的基本蒸汽.

结论:

  • 蛋白质纳米晶体为类似晶体管的响应性材料提供了一个基于生物聚合物的新平台.
  • 响应pH的中尺度组件可为各种应用提供先进的功能.
  • 这一突破对药物封装,生物传感,细胞模拟材料和微流体化学具有重大前景.