非人类免疫缺陷病毒患者的加密球菌脑膜炎的预后因素:使用全国数据库的观察性研究
Hotaka Namie1, Takahiro Takazono1,2, Yusuke Hidaka3
1Department of Infectious Diseases, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Mycoses
|October 9, 2023
概括
非艾滋病毒患者的密码球菌脑膜炎 (CM) 的死亡率更高. 老年,意识受损,血液透析和皮质类固醇使用是这些患者预后不佳的关键预测因素.
科学领域:
- 传染性疾病 传染性疾病
- 菌类学 菌类学是指菌类学.
- 流行病学 流行病学
背景情况:
- 加密球菌脑膜炎 (CM) 是一种严重的真菌感染,死亡率高,特别是在像艾滋病毒感染者这样的免疫功能低下个体中.
- 关于非艾滋病毒患者的CM预后的数据有限,需要进一步研究.
研究的目的:
- 在没有艾滋病毒感染的患者中确定密码球菌脑膜炎 (CM) 的治疗前预后因素.
- 为了比较艾滋病毒阳性和艾滋病毒阴性CM患者之间的死亡率.
主要方法:
- 对2010-2017年日本全国数据进行了大规模的回顾性分析.
- 包括诊断为CM的住院患者.
- 对非艾滋病毒CM患者的预后因素进行全因死亡率和后勤回归分析的比较.
主要成果:
- 该研究分析了533名患者 (64名艾滋病毒感染者,469名非艾滋病毒感染者).
- 非HIV的CM患者的90天死亡率明显高 (25.4%对6.3%).
- 在非艾滋病毒患者中,晚年 (≥65岁),意识受损,血液透析和先前使用皮质类固醇与30天的预后不佳有关.
结论:
- 与艾滋病毒阳性患者相比,非艾滋病毒CM患者的预后较差.
- 老年,意识受损,血液透析和皮质类固醇使用是改善非艾滋病毒性CM的管理所需考虑的关键因素.
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