功能和结构性大脑异常的评估与静止状态的功能性MRI在前庭神经炎患者
QiChao Cheng1, AnLi Ren2, JingYang Han3
1Qilu Hospital of Shandong University, JiNan, Shandong Province, PR China.
Acta radiologica (Stockholm, Sweden : 1987)
|October 9, 2023
概括
静脉神经炎 (VN) 患者表现出大脑活动和结构的改变. 这些关于神经活动,功能连接和灰质体积的发现可能解释了VN的机制.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 放射学 放射学是一门学科.
背景情况:
- 静脉神经炎 (VN) 是一种导致突然,孤立的疾病.
- 有限的研究存在于VN患者的功能和结构性大脑变化.
研究的目的:
- 在VN中调查自发神经活动,功能连接 (FC) 和灰质体积 (GMV) 的变化.
- 为了确定受VN影响的特定大脑区域.
主要方法:
- 使用休息状态功能性MRI (rs-fMRI) 和3D T1加权成像在24名VN患者和22名对照中.
- 对局部异常的低频波动 (ALFF) 的分析幅度,区域同质性 (ReHo) 和中心度 (DC) 的分析.
- 在受影响最严重的区域进行了FC分析,并对GMV差异进行了基于素的形态测量 (VBM).
主要成果:
- 在VN患者中,左舌环和右后中心环的ALFF,ReHo和DC增加.
- 观察到左舌环和其他大脑区域之间发生了改变的FC,包括上额头环,胰岛和上边缘环.
- 在VN患者的双边尾状核中发现了减少的GMV.
结论:
- VN与自发神经活动,FC和GMV的显著异常有关.
- 这些功能和结构性大脑变化为VN的病理生理学提供了洞察力.
- 进一步的研究可以探索这些神经成像发现的诊断和治疗进步.
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