瘤微环境激活纳米复合材料用于自我放大化学动力学/饥饿疗法 增强的IDO-阻断瘤免疫疗法
Yulong Bian1,2, Bin Liu1, Binbin Ding1
1State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|October 9, 2023
概括
这项研究引入了一种新型纳米复合材料,通过破坏瘤细胞的氧化还原平衡和增强免疫反应来增强癌症治疗. 这种方法通过联合疗法有效地抑制瘤生长和转移.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术 纳米技术
- 癌症治疗 癌症治疗
背景情况:
- 瘤治疗受到抑制的免疫微环境和药物输送不良的限制.
- 与免疫检查点阻塞一起破坏细胞内氧化还原稳定,显示出瘤细胞死亡的前景.
研究的目的:
- 构建一个多功能,瘤微环境 (TME) 响应的纳米复合材料,用于联合提供治疗剂.
- 增强对TME反应的药物释放并放大治疗效果.
主要方法:
- 合成的四氧化 (Mn3O4) 装饰的,含有二硫化键的树突性半孔性有机纳米粒子 (DMONs).
- 同时装载的DMON与胺二氧化酶 (IDO) 抑制剂 (Epacadostat, IDOi) 和葡萄糖氧化酶 (GOx) 的抑制剂.
- 改造的纳米颗粒与聚乙烯糖醇用于改善性能.
主要成果:
- 纳米复合材料在TME中迅速分解,有效释放治疗有效载荷.
- Mn3O4催化了H2O2分解,GOx消耗了葡萄糖,Mn2+产生了基 (•OH),破坏了氧化还原稳定.
- 联合化学动力学/饥饿疗法与IDO阻断免疫疗法协同抑制了瘤生长和转移.
结论:
- 开发的纳米复合材料为协同癌症治疗提供了一个有前途的战略.
- 实现了对TME敏感的药物递送和放大治疗效果.
- 这种方法有可能克服当前瘤治疗的局限性.
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