相关实验视频
Updated: Jul 14, 2025

Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice
Published on: February 22, 2019
孕产妇百日咳疫苗接种,婴儿免疫接种,以及百日咳的风险
Annette K Regan1,2,3, Hannah C Moore1,4, Michael J Binks5
1School of Population Health, Curtin University, Perth, Western Australia, Australia.
母亲的百日咳疫苗接种显著降低了婴儿感染的风险通过八个月. 虽然婴儿疫苗的有效性可能会略有下降,但婴儿的整体疾病风险仍然很低.
科学领域:
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 百日咳或百日咳对婴儿构成重大风险.
- 孕产妇百日咳疫苗接种计划旨在在接种疫苗之前保护新生儿.
- 母婴疫苗接种的有效性及其对婴儿疫苗接种计划的影响需要持续评估.
研究的目的:
- 为了估计母性百日咳疫苗接种的疫苗有效性 (VE).
- 为了确定母体疫苗接种是否影响婴儿百日咳疫苗接种系列的有效性.
- 分析随着时间的推移和婴儿年龄的 VE 趋势.
主要方法:
- 一项基于人口的队列研究利用了来自澳大利亚三个司法管辖区的279,418对母婴的行政健康记录.
- 如果婴儿的母亲在分娩前至少14天接种了 pertussis 疫苗,婴儿被归类为母体接种疫苗.
- 婴儿的百日咳感染通过可报告的疾病记录来确定,并使用Cox比例危险模型计算VE.
主要成果:
- 母亲百日咳疫苗接种显示出显著的VE,从两个月以下的婴儿的70.4%降至7-8个月的婴儿的43.3%.
- 在8个月后,VE没有统计学意义.
- 虽然第三剂婴儿 pertussis 疫苗在母体接种疫苗的婴儿中显示出稍低的 VE 估计 (76.5% vs 92.9%),但这与 pertussis 感染率的增加无关.
结论:
- 孕期28周左右进行的孕产妇百日咳疫苗接种与婴儿百日咳感染的风险降低有关,直到8个月大.
- 尽管婴儿疫苗的有效性可能略有降低,但母亲接种疫苗似乎不会增加婴儿咳疾病的总体风险.
更多相关视频
09:09Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using PolyI:C to Study Susceptibility and Resilience in Offspring
Published on: August 17, 2022
05:31Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
Published on: August 7, 2017
相关概念视频
Vaccinations
Development of Immunocompetence
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla. Benzonatate operates peripherally within the respiratory tract by...
Probability Laws
Pneumonia V: Nursing management and Prevention
The nurse must practice strict medical asepsis and adhere to infection control guidelines to minimize healthcare-associated infections.
Enhance airway patency
Position the patient correctly to facilitate drainage of the affected lung segments. Manual or mechanical percussion and vibration can also be employed....
Transmission-based Precautions II: Airborne and Protective Environment
Airborne precautions:
Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...