快速生长的遗传选择对肉木乳腺肌肉病的发展的影响
M Emambu1,2, A Haron1, D Lokshtanov1
1Institute of Animal Science, Agricultural Research Organisation, Volcani Center, Rishon Le Zion, Israel.
British poultry science
|October 9, 2023
概括
快速生长的肉 (Cobb500) 由于生理和分子变化,包括基因表达的改变,与缓慢生长的品种相比,发展出木制乳房 (WB). 这种肌肉肌病与快速增长超越代谢和心脏支持有关.
科学领域:
- 动物科学动物科学
- 家禽遗传学 家禽遗传学
- 肌肉生理学 肌肉生理学
背景情况:
- 木质乳房 (WB) 是一种新出现的肉肌病,其特点是硬的乳房肉.
- 之前的研究表明,快速增长率与西行发展之间存在联系.
- 潜在的生理和分子机制需要进一步研究.
研究的目的:
- 研究导致肉木乳房 (WB) 的生理和分子机制.
- 为了比较快速生长的 (Cobb500) 和缓慢生长的 (L1986) 肉品种在生长,生理学和基因表达方面.
- 识别与WB发展相关的分子标记物.
主要方法:
- 快速生长和缓慢生长的肉品种之间的生长参数,氧气消耗和甲状腺激素水平的比较.
- 从有和没有WB的 brojlers的乳腺肌肉组织中分析基因表达模式.
- 测量乳房的重量,厚度,pH值,保持水分的能力和相对器官重量.
主要成果:
- 木质乳房 (WB) 仅在快速生长的Cobb500系列中观察到,从化后21天开始.
- 与L1986相比,Cobb500肉的生长率,相对乳房重量,厚度,肉的pH值和滴水损失较高,但相对心脏/右心室重量和甲状腺激素水平较低.
- 受WB影响的肌肉表现出差异性的基因表达,与低氧 (PLOD2),再生 (CSRP3) 和纤维类型切换 (ANKRD1) 相关基因的上调,以及能量代谢基因的下调 (CD36).
结论:
- 肉的快速生长选择导致生理和分子适应,使其倾向于木制乳房 (WB).
- 观察到的变化表明肌肉生长需求与心脏和代谢支持系统的能力之间存在不匹配.
- 与缺氧,肌肉再生和能量代谢相关的特定基因与WB病变发生有关.
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