一个包括MPV在食道状细胞癌中的预后诺基图
Qiao He1, Zhenglian Luo2, Haiming Zou1
1Department of Clinical Laboratory, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, China.
Cancer medicine
|October 9, 2023
概括
这项研究开发了一种使用平均血小板体积 (MPV) 和临床病理因素预测食道状细胞癌 (ESCC) 患者整体存活率的诺姆图. 与现有的分期系统相比,名图显示出更好的预测准确性.
科学领域:
- 在瘤学瘤学.
- 血液学 血液学 血液学
- 生物统计学 生物统计学
背景情况:
- 平均血小板体积 (MPV) 是各种癌症中公认的预后生物标志物.
- 用更好的预测工具可以改善食道状细胞癌 (ESCC) 的预后.
研究的目的:
- 开发和验证ESCC患者整体存活期 (OS) 的预后名录.
- 评估MPV作为ESCC中的OS预测器的实用性.
主要方法:
- 一个回顾1893年ESCC患者的队列被分为训练和测试组.
- 通过LASSO-cox,单变体和多变体的 Cox 回归分析,确定了预后变量.
- 使用决策曲线分析 (DCA) 构建和验证了一个名图.
主要成果:
- 年龄,MPV,神经入侵,T阶段和N阶段被确定为独立的预后因素.
- 在两个队伍中,名图显示了对1年,3年和5年的OS的良好预测准确性.
- 诺米图表的性能优于AJCC第8号和传统的分阶段系统.
结论:
- 结合MPV和临床病理标记的新型诺摩图增强了ESCC中的OS预测准确性.
- 该工具为ESCC患者提供了更精确的预后评估.
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