年龄和功能依赖是否会影响同时进行心脏移植的结果?
Iris Feng1, Paul A Kurlansky1,2, Yuming Ning2
1Division of Cardiothoracic and Vascular Surgery, Department of Surgery, Columbia University Irving Medical Center, New York, NY.
JTCVS open
|October 9, 2023
概括
接受同时心移植 (SHK) 的老年患者的存活率与年轻患者相似. 年龄和功能依赖性不是SHK移植后死亡的重要风险因素.
科学领域:
- 心脏病学 心脏病学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 移植医学 移植医学
背景情况:
- 同时心移植 (SHK) 是对末期器官衰竭的复杂手术.
- SHK移植的数量有所增加,年龄较大的接受者参与的比例越来越大.
研究的目的:
- 为了比较SHK移植的年轻 (18-65岁) 与年长 (>65岁) 接受者的特征和结果.
- 评估功能依赖对不同年龄组移植后结果的影响.
主要方法:
- 从联合器官共享网络数据库 (2010-2021) 中对1398名SHK接受者的回顾性分析.
- 不包括18岁以下的患者,移植了其他器官的患者,或先前进行过心脏移植的患者.
- 倾向性得分匹配被用来比较年轻和年长的接受者队列之间的结果.
主要成果:
- 在过去二十年中,每年SHK移植在两个年龄组显著增加.
- 在倾向性得分匹配后,老年接受者 (>65岁) 与年轻接受者 (18-65岁) 相比,移植后死亡率没有增加.
- 无论是年龄还是移植前的功能状况都不是7年SHK移植后死亡率的重要风险因素.
结论:
- 在SHK移植后,老年和功能依赖的接受者不会经历死亡率增加.
- 结果支持对器官分配进行全面的候选人评估,重点关注并发症,而不仅仅是年龄或功能状况.
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