探索结核病控制的程序指标,包括在低发病率环境中进行常规的Mycobacterium结核病测序:全面的 (2017-2021) 患者队列分析
Xiaomei Zhang1,2,3, Elena Martinez2,3,4, Connie Lam2,3
1Centre for Research Excellence in Tuberculosis (TB-CRE), Centenary Institute, Sydney, New South Wales, Australia.
澳大利亚Mycobacterium tuberculosis的常规全基因组测序 (WGS) 提供了有关结核病传播和耐药性的宝贵见解. 这种基因组监测通过识别本地传播模式和改进药物耐药性检测,有助于结核病控制计划.
科学领域:
- * 基因组流行病学
- * 传染病监测 传染病监测 传染病
- * 公共卫生微生物学
背景情况:
- * Mycobacterium 结核病的全基因组测序 (WGS) 越来越常见.
- *除了个人患者管理和药物耐药性检测之外,它对结核病 (TB) 控制计划的实用性仍未得到充分探索.
研究的目的:
- *分析澳大利亚新南威尔士州 (NSW) 结核病例的常规WGS数据.
- * 评估基因组监测对了解局部结核病传播和耐药性模式的价值.
- * 评估WGS作为结核病控制中的程序指标的工具.
主要方法:
- *分析了2017年至2021年期间在新南威尔士州报告的培养确诊结核病例的常规WGS数据.
- *使用单核酸多态 (SNP) 聚类进行基因组监测,以确定局部传播事件.
- *基因型药物敏感性测试 (DST) 检测药物耐药性赋予突变.
主要成果:
- *分析了1831个M.结核病序列,占已报告结核病例的64%以上.
- *使用5-SNP值识别了62个传输集群,揭示了最近可能发生的本地传输.
- * 基因型DST与表型DST具有很高的一致性,药物耐药性检测增加6.8%,并识别错过的突变.
结论:
- * 常规前性WGS为低发病率环境中的结核病控制提供了基因组信息的编程指标.
- * 循环五年集群评估有效监测疫情制和朝着零结核病传播的进展.
- *基因组DST为临床管理和持续的药物耐药性监测提供了关键信息.
更多相关视频
10:04Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates
Published on: September 5, 2017
15:28A Microscopic Phenotypic Assay for the Quantification of Intracellular Mycobacteria Adapted for High-throughput/High-content Screening
Published on: January 17, 2014
相关概念视频
Pulmonary Tuberculosis I
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Pulmonary Tuberculosis IV
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Pulmonary Tuberculosis II
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Pulmonary Tuberculosis V
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
Pulmonary Tuberculosis III
The first classification is based on the development of the disease, and it includes the following categories:
