扩散张力自由水MRI预测在缺血性中风后FLAIR白质超强度的进展
Kyle C Kern1, Marwah S Zagzoug1, Rebecca F Gottesman1
1Stroke Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States.
Frontiers in neurology
|October 9, 2023
概括
在扩散张力成像 (DTI) 上测量为自由水 (FW) 的间歇性液体升高,预测脑小血管疾病患者的白质强度过高 (WMH) 进展.
科学领域:
- 神经成像是一种神经成像.
- 脑血管疾病 脑血管疾病
- 白物质的超强度 白物质的超强度
背景情况:
- 在MRI上白质超强度 (WMHs) 与认知能力下降有关.
- 正常出现的白质 (NAWM) 中的微观结构变化先于WMH的进展.
- 间歇性液体积累可能是脑小血管疾病 (CSVD) 的关键因素.
研究的目的:
- 为了调查在扩散张力成像 (DTI) 上是否存在升高的自由水 (FW),先于WMH进展.
- 为了确定间歇性液体积累是否是CSVD进展的早期病理阶段.
主要方法:
- 在中风或TIA后的患者中,连续脑部MRI在一年内获得.
- 使用自动细分和病变扩张来评估WMH进展.
- 分析了包括FW在内的DTI指标,以预测WMH半影中的WMH进展.
主要成果:
- 观察到年均WMH增长的中位数为2.9 ± 2.6毫升.
- 在DTI上的基线FW显示了WMH进展的最高预测值 (AUC = 0.732).
- 所有DTI指标都与半阴影中的病变进展有关.
结论:
- 在DTI上增加的间歇性液体 (FW) 预测了NAWM向WMH的进展.
- 这些发现表明FW与CSVD进展的病原体有关.
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