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结核病的临床和流行病学特征:一项回顾性研究
Keke Sun1, Zhenhua Shi1,2, Yushanjiang Abudureheman1,3
1Department of Emergency Medicine, Tianjin Medical University General Hospital, Tianjin, China.
International journal of clinical practice
|October 9, 2023
概括
轮骨髓溶解 (RM) 可以导致急性损伤 (AKI). 酒精消耗,肌酸激酶 (CK) 和肌酸氨酸是RM患者AKI的关键危险因素. 结合CK和肌素可以提供更好的预测.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 内部医学 内部医学
- 临床研究 临床研究
背景情况:
- 轮骨髓溶解 (RM) 是肌肉细胞损伤的综合征,其症状包括肌肉疼痛,软弱和阴色的尿液.
- 急性损伤 (AKI) 是RM的一种严重并发症,其特点是复杂的机制和高死亡率.
- 早期诊断和了解RM病原体对于改善患者预后至关重要.
研究的目的:
- 分析Rhabdomyolysis (RM) 患者的临床和实验室特征.
- 确定RM患者急性损伤 (AKI) 的独立风险因素.
- 评估肌酸激酶 (CK) 和肌因在RM中的AKI的预测值.
主要方法:
- 来自天津医科大学总医院 (2019年10月 - 2022年10月) 的71名Rhabdomyolysis (RM) 患者的医疗记录的回顾性分析.
- 后勤回归分析以确定RM复杂性AKI的风险因素.
- 接收器运行特征 (ROC) 曲线分析以确定肌酸激酶 (CK) 和肌酸氨酸的预测值.
主要成果:
- 该研究包括71名RM患者,平均年龄为53.0岁;男性患病率比女性高2.5倍.
- 感染是RM最常见的原因.
- 酒精消费史,肌酸激酶 (CK) 和肌酸氨酸水平升高被确定为RM患者AKI的独立风险因素.
- 后勤回归表明,CK和肌素的组合与单独的标志物相比,对AKI具有更高的预测价值.
结论:
- 这项研究提供了有关RM和相关AKI在特定患者群体中的临床和实验室特征的见解.
- 酒精消耗,CK和肌是影响RM AKI发展的重要因素.
- 对CK和肌素的联合评估表明,在RM患者中,AKI的预测能力提高,指导临床管理.
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