青少年的寡基生和髓化限制了成年视觉皮层中经验依赖的神经元可塑性
Wendy Xin1, Megumi Kaneko2, Richard H Roth3
1Department of Neurology, Weill Institute for Neurosciences, University of California San Francisco.
bioRxiv : the preprint server for biology
|October 9, 2023
概括
骨髓质细胞的形成稳定了神经元电路并限制了可塑性. 在小鼠中抑制寡基细胞成熟,使小鼠在成年时保持可塑性,证明了髓在电路稳定中的作用.
科学领域:
- 神经科学是一个神经科学.
- 发展生物学 发展生物学
- 细胞生物学 细胞生物学
背景情况:
- 发育性髓化是哺乳动物大脑中的一个缓慢的过程.
- 寡头细胞的成熟可能会稳定神经元电路,并随着年龄的增长缓和可塑性.
- 视觉皮层对可塑性有一个定义的临界期.
研究的目的:
- 研究髓在稳定神经元电路中的作用.
- 为了确定髓是否在发育过程中抑制神经元可塑性.
主要方法:
- 在青少年小鼠中,在寡干细胞前体细胞 (Myrf cKO) 中条件删除了Myrf基因.
- 在成年对照和Myrf cKO小鼠中的单眼剥夺.
- 在体内内存在的内在信号光学成像和树突的纵向双光子成像,以评估可塑性.
主要成果:
- 甲状腺的缺失抑制了小寡腺细胞的成熟和髓化到成年期.
- 在单眼剥夺后,Myrf cKO小鼠表现出视觉皮层可塑性增加,类似于青少年小鼠.
- 在单眼剥夺后,Myrf cKO小鼠显示树突脊柱密度降低,脊柱周转率增加,脊柱大小协调下降.
结论:
- 寡细胞在塑造皮质电路成熟和稳定方面发挥着至关重要的作用.
- 髓在发育过程中起到抑制神经元可塑性的作用.
- 髓在电路稳定中的作用对于限制成人大脑的可塑性至关重要.
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