精神病学多基因分数,医疗保健利用率和并发症负担之间的关联
H Lester Kirchner1, Daniel Rocha2, Richard K Linner3
1Department of Population Health Sciences, Geisinger, Danville PA.
medRxiv : the preprint server for health sciences
|October 9, 2023
概括
大型抑郁症的遗传风险与更高的医疗保健使用率和更多的健康问题有关. 这种遗传倾向预测了慢性疾病的利用率和负担的增加,即使没有诊断.
科学领域:
- 精神病学遗传学 精神病学遗传学
- 医疗保健服务研究 医疗服务研究
- 基因组学就是基因组学.
背景情况:
- 精神病学多基因分数 (PGS) 提供了对心理健康状况的遗传倾向的见解.
- 了解遗传风险对医疗保健利用和并发症的现实影响对于公共卫生至关重要.
- 以前的研究已经探索了与精神疾病的遗传联系,但与医疗保健资源利用的关联需要进一步调查.
研究的目的:
- 研究精神病学多基因分数 (PGS) 与医疗保健利用率之间的关联.
- 在一个大队伍中估计PGS和并发症负担之间的关系.
- 为了确定抑郁症,双相情感障碍和精神分裂症的遗传风险是否会影响医疗保健资源的使用.
主要方法:
- 一项观察性队列研究包括来自三个生物库的118,882名参与者,这些生物库与链接的电子健康记录 (EHR) 有关.
- 多基因分数 (PGS) 使用全基因组关联研究 (GWAS) 数据计算主要抑郁症,双相情感障碍和精神分裂症.
- 负二项回归模型评估了PGS与医疗保健利用 (急诊室,住院,门诊) 和并发症指数 (Elixhauser,Charlson) 之间的关联.
主要成果:
- 大型抑郁症 (PGS) 的最高分位数中的个体显著增加了急诊室的访问 (RR=1.22) 和更大的并发症负担.
- 在抑郁症诊断后,主要抑郁症PGS与所有医疗保健利用类型 (ED,OP,IP) 的进一步增加有关.
- 对于双相情感障碍或精神分裂PGS与医疗保健利用率或并发症负担没有发现临床上有意义的关联.
结论:
- 抑郁症的多基因分数与医疗保健资源利用率增加和并发症负担的增加有着适度的关联,这与诊断无关.
- 通过PGS测量抑郁症的遗传风险,与现实世界医疗保健环境中的更高的利用率和慢性疾病负担有关.
- 这些发现突显了PGS在预测医疗保健需求和管理患有抑郁症遗传倾向的个体的慢性疾病方面的潜力.
相关概念视频
Human Genetics
590
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
590
Diagnostic and Statistical Manual of Mental Disorders (DSM)
66
The Diagnostic and Statistical Manual of Mental Disorders (DSM) serves as the primary classification system for mental health disorders, providing standardized diagnostic criteria for clinicians and researchers. First published by the American Psychiatric Association (APA) in 1952, the DSM has undergone several revisions to reflect evolving psychiatric understanding. The fifth edition, DSM-5, released in 2013, introduced key updates that expanded diagnostic categories and modified diagnostic...
66
Polygenic Traits
66.0K
When more than one gene is responsible for a given phenotype, the trait is considered polygenic. Human height is a polygenic trait. Studies have uncovered hundreds of loci that influence height, and there are believed to be many more. Due to the high number of genes involved, as well as environmental and nutritional factors, height varies significantly within a given population. The distribution of height forms a bell-shaped curve, with relatively few individuals in the population at the...
66.0K
Genome-wide Association Studies-GWAS
13.5K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
13.5K
Psychological and Sociocultural Causes of Schizophrenia
96
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
96
Bulimia Nervosa
127
Bulimia nervosa is a complex and severe eating disorder characterized by a cyclical pattern of binge-and-purge eating pattern. It generally involves an episode of binge eating, followed by compensatory behaviors such as vomiting, excessive exercise, laxative use, or fasting, to prevent weight gain. Despite often maintaining a normal weight, individuals with bulimia are intensely preoccupied with their body image and harbor an overwhelming fear of gaining weight. This can contribute to the...
127


