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Updated: Jun 19, 2026

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
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Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs

Published on: May 15, 2019

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发现了SARS-CoV-2主要蛋白酶的第一类PROTAC降解剂

Yugendar R Alugubelli, Jing Xiao, Kaustav Khatua

    bioRxiv : the preprint server for biology
    |October 9, 2023
    PubMed
    概括

    新的PROTAC技术针对SARS-CoV-2主要蛋白酶 (M Pro) 进行COVID-19治疗. 这种方法降解病毒蛋白质,为有效的抗病毒药物开发提供了传统抑制剂的有希望的替代方案.

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