鱼油补充剂改变了血脂的遗传潜力
Yitang Sun1, Tryggvi McDonald1, Abigail Baur1
1Department of Genetics, Franklin College of Arts and Sciences, University of Georgia, Athens, GA, USA.
medRxiv : the preprint server for health sciences
|October 9, 2023
概括
鱼油补充剂可以降低高总胆固醇,LDL-C和甘油三的遗传风险. 它还增加了更高的HDL-C的遗传潜力,这表明对脂质水平有好处.
科学领域:
- 心血管健康 心血管健康
- 遗传学 是一个遗传学.
- 营养科学 营养科学
背景情况:
- 脱脂症是心血管疾病的主要危险因素,是全球主要的死亡原因.
- 众所周知,鱼油具有潜在的心脏保护作用,特别是降低甘油三.
- 鱼油和遗传倾向导致脱脂症之间的相互作用需要进一步研究.
研究的目的:
- 调查鱼油补充剂是否会改变对循环脂水平的遗传倾向.
- 评估对总胆固醇,LDL-C,HDL-C和甘油三的影响.
- 探索这些跨多元祖先的相互作用.
主要方法:
- 利用了441,985名英国生物库参与者的遗传和表型信息数据.
- 对不同祖先的参与者计算的多基因分数 (PGS).
- 采用了多变量线性回归模型,调整了相关风险因素.
主要成果:
- 在欧洲祖先的参与者中,鱼油减轻了对高总胆固醇,LDL-C和甘油三的遗传敏感性.
- 补充剂放大了欧洲祖先个体增加HDL-C的遗传潜力.
- 在非洲祖先的参与者中观察到,对高甘油三的遗传倾向有显著的减弱.
结论:
- 鱼油补充剂减少了对高总胆固醇,LDL-C和甘油三酸的遗传敏感性.
- 它突出了更高的HDL-C的遗传潜力,表明具有有益作用.
- 鱼油可能有利地改变全基因组对一般人群脂质水平的遗传效应.
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