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Updated: Jul 14, 2025

Quantitative Mapping of Specific Ventilation in the Human Lung using Proton Magnetic Resonance Imaging and Oxygen as a Contrast Agent

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使用向分子成像探测器对辐射诱导的肺损伤进行非侵入性量化

Eric Abston¹, Iris Y Zhou^2,3,4, Jonathan A Saenger³

¹Division of Thoracic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

medRxiv : the preprint server for health sciences

|October 9, 2023

概括

一种针对1型原蛋白的新型分子成像探针可以在临床前模型和人类患者中非侵入性地检测和量化辐射诱导的肺损伤 (RILI). 这一进展有助于评估RILI的严重程度和治疗反应.

科学领域:

分子成像学分子成像学
在瘤学瘤学.
肺部医学肺部医学

背景情况:

辐射诱导性肺损伤 (RILI) 是肺癌放射治疗后的渐进性炎症状况,导致肺炎和纤维化.
目前的RILI管理受到缺乏准确,非侵入性疾病量化方法的阻碍.
目前还没有批准的RILI治疗方法,强调需要改进的诊断工具.

结论:

针对1型原蛋白的分子成像探针可以在临床前和人类环境中有效检测RILI.
这种方法为评估RILI严重性和潜在监测治疗干预提供了一个有希望的工具.
对原蛋白的向分子成像代表了辐射诱导的肺损伤管理的重大进步.

关键词:

生物标志物生物标志物分子成像学分子成像学定量成像技术定量成像技术辐射诱导的肺损伤

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