2023年的粘菌菌病:关于病原和管理的最新情况
Abdullah Alqarihi1, Dimitrios P Kontoyiannis2, Ashraf S Ibrahim1,3
1Division of Infectious Diseases, The Lundquist Institute for Biomedical Innovation at Harbor-University of California Los Angeles (UCLA) Medical Center, Torrance, CA, United States.
Frontiers in cellular and infection microbiology
|October 9, 2023
概括
粘菌 (MCR) 是一种致命的真菌感染,通常与糖尿病和免疫抑制有关. 早期诊断和多学科治疗,包括抗真菌药物和治疗潜在疾病,对于患者的生存至关重要.
科学领域:
- 菌类学 菌类学是指菌类学.
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
背景情况:
- 粘菌 (MCR) 是一种严重的真菌感染,由Mucorales引起,在免疫功能低下的个体中经常致命,特别是那些患有糖尿病 (DM) 和糖尿病酸 (DKA) 的人.
- 由于COVID-19大流行,MCR病例急剧增加,通常与不受控制的DM和皮质类固醇使用有关.
- MCR呈现多种不同的临床形式,包括犀牛轨道/大脑,中肺和皮肤,影响各种宿主类型.
研究的目的:
- 审查了解菌菌病 (MCR) 病原体,诊断和治疗方面的最新进展.
- 突出新型抗真菌疗法对 Mucorales 的迫切需要.
主要方法:
- 文献综述侧重于MCR病原性,宿主-病原体相互作用和治疗策略.
- 对最近的分子诊断和治疗发展进行分析.
主要成果:
- 致病性见解包括宿主受体 (GRP78),信号通路 (EGFR),铁的可用性和真菌毒素.
- 需要注意的是,在培养独立分子诊断方面的进展.
- 开发新的强效抗真菌药物来对抗真菌菌仍然是一个重要的未满足的需求.
结论:
- 有效的MCR管理需要高的怀疑指数,用于早期诊断和启动Mucorales活性抗真菌药物.
- 涉及免疫抑制逆转,DKA纠正和手术干预的多学科治疗改善了结果.
- 对新型抗真菌药物进行进一步的研究和了解MCR病原体至关重要.
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