皮肤中存在的抗病毒T细胞对大酶C的广泛和动态表达
Ramon A Lujan1,2, Luxin Pei1, John P Shannon1
1Viral Immunity and Pathogenesis Unit, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, United States.
Frontiers in immunology
|October 9, 2023
概括
大酶C被皮肤抗病毒T细胞广泛表达,包括树突性表皮T细胞和CD8+组织内存T细胞. 它的表达受到感染和IL-15的影响,这表明其作用超出了细胞杀死范围.
科学领域:
- 免疫学 免疫学 免疫学
- 细胞生物学 细胞生物学
- 病毒学 病毒学
背景情况:
- 效应体CD8+ T细胞使用酶和穿孔素在抗病毒反应期间杀死细胞.
- 精确的功能,大酶C和其人类的正方体,大酶H,仍然在很大程度上是未知的.
- 大酶C是由先天性淋巴1细胞 (ILC1s) 构成性表达的.
研究的目的:
- 为了研究各种小鼠皮肤内抗病毒淋巴细胞中的大酶C表达.
- 为了确定这些细胞中酶C的表达是否构成性或环境响应性.
- 探索通过T细胞受体 (TCR) 参与和细胞因子调节大酶C表达的调节.
主要方法:
- 在树突性表皮T细胞 (DETCs) 和皮肤 γδ T 细胞中分析大酶 C 表达.
- 评估CD8+组织寄存记忆T细胞 (T_RM) 疫苗接种后病毒 (VACV) 感染中的大酶C表达.
- 在局部VACV感染和IL-15治疗时对大酶C上调的评估.
主要成果:
- 脑膜上皮层T细胞 (DETCs) 在平衡状态下表达了大酶C,而皮肤 γδ T 细胞没有.
- 在VACV感染后产生的CD8+组织内存T细胞 (T_RM) 也表达大酶C.
- 在对局部VACV感染和IL-15治疗的反应中,DETC和病毒特异的CD8+T_RM都提高了C粒酶的调节,TCR参与促进了表达.
结论:
- 大酶C广泛表达于居住在皮肤中的抗病毒T细胞.
- 这些细胞中的大酶C表达是由环境线索动态调节的,包括病毒感染和IL-15.
- 这些发现表明,酶C在组织寄存淋巴细胞中具有潜在的非细胞分解功能.
相关概念视频
Cytotoxic T Cells-mediated Immune Response
955
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
955
Immune Response Against Viral Pathogens
804
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
804
Cells of the Innate Immune Response
1.7K
The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
1.7K
Cell-mediated Immune Responses
68.7K
Overview
68.7K
Antigens Involved in Adaptive Immunity
516
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
Complete Antigens
Complete antigens possess both immunogenicity and...
516
Immune Surveillance by NK Cells and Phagocytes
1.4K
Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
1.4K


