表观遗传向增强急性髓性白血病导向免疫疗法
Johanna Rausch1,2, Evelyn Ullrich2,3,4,5, Michael W M Kühn1,2
1Department of Hematology and Medical Oncology, University Medical Center, Johannes Gutenberg-University, Mainz, Germany.
Frontiers in immunology
|October 9, 2023
概括
免疫疗法在与表观遗传药物结合使用时,对急性髓性白血病 (AML) 有希望. 这些向疗法可以增强免疫反应,并改善AML患者的治疗结果不符合化学疗法的.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
背景情况:
- 急性髓性白血病 (AML) 治疗结果不佳,特别是对于无法接受强化化疗的患者.
- 虽然免疫疗法已经推进了固体瘤和淋巴瘤,但在AML中的成功是有限的,这是由于低突变负担和缺乏AML特异性抗原.
- 表观遗传失调驱动白血病发生,低甲基化剂 (HMA) 构成非密集型AML治疗的基础.
研究的目的:
- 探索结合表观遗传药物与免疫疗法的潜力,以提高AML治疗疗效.
- 调查向表观遗传疗法如何使AML对基于免疫的治疗敏感.
主要方法:
- 对评估HMA与免疫检查点抑制剂的临床试验的综述.
- 选择性第二代表观遗传抑制剂的临床前评估,针对染色质调节剂.
- 对表观遗传药物可能增强抗白血病免疫反应的机制的分析.
主要成果:
- 将HMA与免疫检查点抑制剂相结合显示出适度的疗效,对抗CD47抗体加上阿扎西提丁的显著成功.
- 选择性表观遗传抑制剂显示出有希望的临床前活性,诱导白血病细胞分化.
- 表观遗传药物可以通过调节免疫检查点,创造有利于炎症的环境和增加抗原表达来提高AML的敏感性.
结论:
- 将向表观遗传药物与细胞免疫疗法相结合,为改善AML治疗疗效和最大限度地减少副作用提供了一个有希望的策略.
- 需要进一步的研究来阐明这些表观遗传化合物对临床转化影响的特定免疫功能.
关键词:
急性骨髓性白血病 (AML) 是一种急性骨髓性白血病.细胞疗法是细胞疗法.检查点抑制抑制检查点的抑制染色体修饰剂 染色体修饰剂组合疗法治疗组合治疗.表观遗传学是指表观遗传学.低甲基化剂是一种低甲基化剂.免疫疗法 免疫疗法更多相关视频
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