COVID-19 患者在淋巴细胞子集中表现出变化,CD8lo T 细胞功能失调的频率更高,与疾病严重程度相关
Luisina Ines Onofrio1,2, Constanza Marin1,2, Jeremías Dutto1,2
1Departamento de Bioquímica Clínica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina.
COVID-19改变了细胞免疫力,增加了B细胞和减少了T细胞. 一种新的CD8-hi/CD8-lo T细胞比率显示出作为疾病严重程度和患者分层的生物标志物具有前途.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 临床医学 临床医学
背景情况:
- COVID-19是由SARS-CoV-2引起的.
- 细胞免疫在对病毒感染的反应中起着至关重要的作用.
- 了解COVID-19中的免疫细胞动态对于疾病管理至关重要.
研究的目的:
- 为了研究阿根廷患者对SARS-CoV-2的细胞免疫力.
- 为了比较在不同波的流行病期间的免疫反应.
- 为了确定COVID-19严重程度和进展的潜在生物标志物.
主要方法:
- 流细胞计用于分析周围血液淋巴细胞群体.
- 患有中度和重度COVID-19的患者与健康的捐赠者进行了比较.
- 评估了免疫细胞的频率和标记物表达 (GZMB,CD107a,CD39,PD-1,IL-2,TNF,IFN-γ).
主要成果:
- 在COVID-19患者中,B细胞增加,CD3+T细胞减少.
- 调控性T细胞 (Tregs) 减少,特别是在严重的病例中.
- 在COVID-19患者中观察到CD8-低T细胞的显著增加,与疾病严重程度相关.
- CD8-hi/CD8-lo T细胞指数改善了临床分层和结果预测.
结论:
- COVID-19显著破坏细胞免疫力,影响T和B细胞种群.
- CD8-hi/CD8-lo T细胞比率是预测COVID-19疾病进展的潜在生物标志物.
- 这一指数可以提高COVID-19患者的临床分层和治疗管理.
更多相关视频
07:17Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice
Published on: June 22, 2016
05:03Author Spotlight: Elucidating the Pathways of TFH Cell Differentiation in Acute LCMV Challenges
Published on: April 26, 2024
相关概念视频
T Cell Types and Functions
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Immunodeficiency Diseases
There are three main causes of immunodeficiency...
Immune Response Against Viral Pathogens
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
T Cell Activation and Clonal Selection
Naive T cells that have not yet encountered an antigen express two primary CD...
Disorders of Leukocytes
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
COPD: Pathogenesis and Clinical Features
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
