复发性血管免疫细胞T细胞淋巴瘤的第一个迹象:皮肤表现
Guy Charest1, Michael McBride1, Amanda K Thomas2
1Dermatology, HonorHealth Dermatology Residency Program, Scottsdale, USA.
Cureus
|October 9, 2023
概括
血管免疫原性T细胞淋巴瘤 (AITL) 可能会出现皮肤问题. 这一案例强调皮肤发现是复发性AITL的初始迹象,强调需要进行彻底的诊断.
科学领域:
- 在瘤学瘤学.
- 皮肤病学 皮肤病学
- 免疫学 免疫学 免疫学
背景情况:
- 血管免疫原性T细胞淋巴瘤 (AITL) 是一种带有多种临床表现的外围T细胞淋巴瘤.
- 皮肤上的AITL的表现是多种多样的,包括皮疹,结节和红皮.
研究的目的:
- 报告一种罕见的复发性AITL病例,最初出现皮肤发现.
- 详细介绍皮肤AITL的组织病理学和分子特征.
主要方法:
- 皮肤活检的组织病理学检查.
- 对于PD-1,CD3,CD5和BCL-6的免疫组织化学.
- 在Epstein-Barr病毒 (EBV) 的局部杂交.
- 骨髓活检与淋巴细胞透分析和TCR基因重组.
主要成果:
- 皮肤活检显示,淋巴细胞透物对PD-1,CD3,CD5和焦点BCL-6呈阳性.
- 在皮肤透物中发现了EBV阳性细胞.
- 骨髓活检显示了一种非典型的淋巴细胞透与EBV阳性细胞和克隆性TCRβ基因重排.
- 确立了皮肤参与的复发性AITL的诊断.
结论:
- 皮肤上的发现可能是复发性AITL的第一个表现.
- 这一案例凸显了在患有不明原因皮肤病变的患者中考虑AITL的重要性.
- 多方面的诊断方法对于识别AITL复发至关重要.
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