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基于网络分析的研究,与 Xiang-Sha-Liu-Jun-Zi-Tang 的胃癌治疗相关的研究

Ke Jiang^1,2,3,4, Heli Liu⁵, Jie Ge⁵

¹Institute of Integrative Medicine, Department of Integrated Traditional Chinese and Western Medicine, Xiangya Hospital, Central South University, Changsha, 410008, PR China.

|October 9, 2023

概括

传统中医药中的"翔沙柳俊齐唐"通过向关键途径,有效治疗胃癌 (GC). 主要成分奎尔赛丁在抑制GC细胞增殖和促进细胞亡方面表现有前途.

科学领域:

传统中国医药传统中国医药
在瘤学瘤学.
药理学药理学是指药理学的学科.

背景情况:

雄沙柳俊齐唐 (XSLJZT) 是一种广泛使用的传统中医药配方,用于治疗胃癌 (GC).
基于XSLJZT对GC的治疗作用的精确分子机制在很大程度上仍未被探索.
了解这些机制对于优化其临床应用和开发新型癌症疗法至关重要.

研究的目的:

阐明XSLJZT在治疗胃癌 (GC) 的分子机制.
在XSLJZT配方中识别活性成分及其相应的分子标.
通过计算和实验方法验证关键化合物和点的治疗潜力.

主要方法:

构建一个"XSLJZT-活性成分-目标"网络和功能丰富分析 (GO,KEGG).
分子对接模拟以评估活性成分与核心标的结合亲和力.
权重基因共同表达网络分析 (WGCNA),ROC评估,CIBERSORT免疫透分析和细胞实验.

主要成果:

克尔西丁,阴性杆菌醇和纳灵宁被确定为主要的活性成分,向STAT3,TP53和MAPK3,参与IL-17,TNF和HIF-1信号通路.
分子对接表明,奎尔丁对核心标具有强烈的结合亲和力,包括TP53,MMP9,TIMP1和MYC.
细胞实验证实氨酸抑制GC细胞增殖并促进细胞亡,其中TP53,MYC和TIMP1被确定为关键标.

结论:

奎尔是XSLJZT的主要活性成分,负责其抗胃癌作用.
治疗机制包括在特定信号通路 (TNF,IL-17) 中准TIMP1,TP53和MYC等关键分子.
XSLJZT,特别是其成分素,在胃癌治疗中具有显著的治疗潜力.

关键词:

GC GC GC GC GC GC GC GC GC GC GC 作用机制作用机制分子对接分子对接网络药理学网络药理学在WGCNA中,WGCNA是WGCNA.XSLJZTT 的时间.

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