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探索改善抗瘤效率的新策略:针对活性氧物种的潜力
Rumbidzai Sharon Chasara1, Taiwo Oreoluwa Ajayi1, Dineo Motjoadi Leshilo1
1Department of Pharmaceutical Sciences, School of Pharmacy, Sefako Makgatho Health Sciences University, Pretoria, 0204, South Africa.
Heliyon
|October 9, 2023
概括
纳米技术提供了针对性地提供药物,以改变瘤微环境 (TME) 内的活性氧物种 (ROS). 这种方法通过精确控制ROS水平以改善治疗结果来提高癌症治疗效率.
科学领域:
- 在瘤学瘤学.
- 纳米医学是一种纳米医学.
- 生物化学 生物化学
背景情况:
- 瘤微环境 (TME) 显著影响癌症的进展和治疗反应.
- 反应性氧物种 (ROS) 在癌症中起着双重作用,在低度时充当信号分子,在高度时诱导损伤.
- 目前的癌症疗法缺乏时空精度,导致异于目标的毒性和低于最佳的剂量.
研究的目的:
- 审查纳米技术在TME中调节ROS中的作用,以加强癌症治疗.
- 探索纳米载体如何实现针对性向瘤输送ROS调节剂.
- 讨论纳米技术在控制ROS水平以提高抗瘤功效方面的潜力.
主要方法:
- 关于纳米技术在癌症治疗中的应用现有文献的综述.
- 对ROS诱导剂的基于纳米粒子的输送系统的分析.
- 探索各种纳米输送系统,如脂质体和纳米囊,用于ROS调节.
主要成果:
- 纳米技术使ROS诱导剂在TME内有针对性的积累成为可能.
- 工程纳米颗粒可以控制释放剂以调节ROS水平 (上调或下调).
- 纳米输送系统通过精确改变ROS平衡来提高抗瘤效率.
结论:
- 使用纳米技术在TME中向调节ROS,为晚期癌症治疗提供了一个有希望的策略.
- 纳米载体提供了一个平台,可以精确地输送和控制治疗剂的释放,最大限度地减少非目标效应.
- 纳米输送系统的进一步开发有可能克服传统癌症治疗的局限性.
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