相关实验视频

Updated: Jul 14, 2025

Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT

Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT

Published on: January 22, 2018

全身动态F-FDG PET/CT Patlak在扩散大B细胞淋巴瘤中的预后值18

Jiankang Yin¹, Hui Wang², Gan Zhu²

¹School of Basic Medical Sciences, Anhui Medical University, Hefei, PR China.

|October 9, 2023

概括

临时全身动态18F-FDG PET/CT帕特拉克成像,特别是Kimax参数,准确预测扩散型大B细胞淋巴瘤 (DLBCL) 患者的预后. 这种方法提供了优越的预测价值超过SUVmax和中期治疗反应的生存结果.

科学领域:

核医学就是核医学.
在瘤学瘤学.
放射学放射学是一门学科.

背景情况:

扩散性大B细胞淋巴瘤 (DLBCL) 是一种侵略性的非霍奇金淋巴瘤.
准确的预后标记对于优化DLBCL治疗策略至关重要.
临时正子发射断层扫描/计算机断层扫描 (PET/CT) 越来越多地用于评估治疗反应.

研究的目的:

在DLBCL患者中调查18F-氧糖PET/CT (18F-FDG PET/CT) 帕特拉克参数的临时全身动态预后意义.
估计动态18F-FDG PET/CT Patlak参数对2年无进展生存 (PFS) 和整体生存 (OS) 的预测值.

主要方法:

从67名DLBCL患者的临时全身动态18F-FDGPET/CT扫描进行了回顾性分析.
使用接收器操作特征 (ROC) 曲线分析SUVmax和Kimax的预测值.
使用卡普兰-梅尔曲线和日志等级测试进行生存分析;对预后因素进行单变量和多变量分析.

主要成果:

在平均18个月的随访后,31.3%的患者出现了疾病复发或死亡.
在多变量分析中,基最大值 (切断值0.13μmolmin-1·ml-1) 和临时治疗反应是PFS和OS的独立预测指标.
与SUVmax (截止值6.1) 和临时治疗反应相比,Ki max显示出更高的预测值.

结论:

临时全身动态18F-FDG PET/CT Patlak成像在DLBCL中提供了显著的预后价值.
动态参数Ki max是对患者预后的强有力的预测指标,表现优于SUVmax.
结合Ki max和临时治疗反应的预测模型准确地分层了DLBCL的预后风险.

关键词:

18F - - 化氧糖糖 - - 化氧糖扩散大的B细胞淋巴瘤.帕特拉克 (Patlak) 是一个古老的城市.全身动态PET/CT全身动态

更多相关视频

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates

Published on: September 5, 2017

Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer

Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer

Published on: July 21, 2018

相关概念视频

Positron Emission Tomography

Positron Emission Tomography

Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...