肥胖与败血症患者死亡率的关联:从观察证据的元分析
Liang Gao1,2, Jun Jin Liu1,2, Qi Chao Fan1,2
1Department of Infectious Disease, The First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, China.
Heliyon
|October 9, 2023
概括
肥胖和超重与较低的败血症死亡风险有关,而低体重会增加死亡风险. 这表明在败血症患者的结果中存在"肥胖悖论".
科学领域:
- 关键护理医学 关键护理医学
- 流行病学 流行病学
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 败血症是一种危及生命的器官功能障碍,是由宿主对感染反应失调引起的.
- 身体质量指数 (BMI) 类别与败血症死亡率之间的关系仍然不完全理解.
- 以前的研究已经产生了相互矛盾的结果,关于体重状况对败血症结果的影响.
研究的目的:
- 调查肥胖,超重和低体重与败血症相关死亡率之间的关联.
- 为了澄清这一问题,
- 肥胖的悖论 肥胖的悖论
- 在败血症的背景下.
- 为了确定体重作为毒症死亡率的潜在风险因素.
主要方法:
- 在主要数据库 (PubMed,科学网,EMBASE,科克兰图书馆) 进行了全面的系统文献搜索,截至2023年3月.
- 来自12项符合条件的研究数据的元分析,涉及521,207人.
- 使用Stata软件 (16.0版本) 进行的统计分析.
主要成果:
- 肥胖与败血症患者的死亡风险降低有关 (OR = 0.82;95% CI:0.69-0.97;P < 0.001).
- 超重也与减少败血症死亡率有关 (OR = 0.83; 95% CI: 0.73-0.94; P < 0.001).
- 低体重成为增加败血症死亡率的独立危险因素 (OR = 1.43; 95% CI: 1.16-1.76; P = 0.038).
结论:
- 一个显著的一个显著的一个显著的.
- 肥胖的悖论 肥胖的悖论
- 对于败血症的死亡率,肥胖和超重是保护性的.
- 低体重被认为是败血症患者死亡的重要独立风险因素.
- 体重状况是影响败血症结果的关键因素,需要进一步调查.
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