怀孕早期母亲的维生素D缺乏以及围产期和长期结果
Soo Bin Lee1, Sang Hee Jung1, Hanna Lee1
1Department of Obstetrics and Gynecology, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, South Korea.
Heliyon
|October 9, 2023
概括
在怀孕早期,母亲的维生素D缺乏 (<10 ng/mL) 会增加早产和儿童发育迟缓的风险. 这项研究强调了怀孕期间监测维生素D水平的重要性,以改善周产期和长期婴儿的结果.
科学领域:
- 产科和妇科 产科和妇科
- 儿科神经学 儿科神经学
- 营养科学 营养科学
背景情况:
- 维生素D缺乏症在孕妇中很普遍.
- 现有研究表明,维生素D缺乏与妊娠高血压,糖尿病和早产等不良产科结果之间存在联系.
- 对儿童长期发展的影响仍然不太了解.
研究的目的:
- 调查第一季度母亲维生素D缺乏与围产期结果之间的关联.
- 评估母亲维生素D缺乏对儿童神经发育结果的潜在影响.
- 为了解怀孕期间维生素D状况的重要性提供见解.
主要方法:
- 对1079名单身孕妇 (2017-2021) 的数据进行了回顾性分析.
- 排除具有先前存在的医疗或手术并发症的妇女.
- 对产科,围产和神经发育结果的评估 (贝利-III,GMFM,图表审查).
主要成果:
- 在第一季度,62.0%的女性观察到维生素D缺乏 (<20 ng/mL);26.7%的女性严重缺乏 (<10 ng/mL).
- 严重的维生素D缺乏 (<10 ng/mL) 与37周前早产风险增加显著相关 (aOR=7.78).
- 严重缺乏也与儿童发育迟缓的风险更高相关 (aOR=4.28).
结论:
- 这项研究是第一个将母亲的第一季度维生素D缺乏与围产期和长期儿童发育结果联系在一起的研究.
- 怀孕早期维生素D水平低于10ng/mL可能会增加早产和发育迟缓的风险.
- 在怀孕期间确保足够的维生素D水平对于优化儿童健康结果至关重要.
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