在油在水乳液和固体分散中,g-瑞的自我稳定性能
Noamane Taarji1,2,3, Meryem Bouhoute1, Lorena de Oliveira Felipe4
1Alliance for Research on the Mediterranean and North Africa (ARENA), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-0006, Japan.
Heliyon
|October 9, 2023
概括
γ-oryzanol 具有自我稳定性,可以在没有乳化剂的情况下使用溶剂位移法 (SDM) 实现稳定的合体系统. 这种方法避免了在高压均质化 (HPH) 中出现的不稳定性问题.
科学领域:
- 合体和表面化学
- 材料科学 材料科学 材料科学
- 制药技术 制药技术 制药技术
背景情况:
- γ-oryzanol的表面活性对于开发稳定的体系统至关重要.
- 像高压均质化 (HPH) 这样的传统方法可能会面临某些化合物的挑战.
- 对生物活性化合物来说,研究稳定封装的替代方法至关重要.
研究的目的:
- 使用吊滴法 (PDM) 评估γ-瑞的表面活性.
- 通过高压同质化 (HPH) 和溶剂位移方法 (SDM) 调查γ-瑞的自我稳定性.
- 确定在没有合成乳化剂的情况下创建稳定的合体系统的可行性.
主要方法:
- 悬挂掉落方法 (PDM) 用于表面活动评估.
- 高压均质化 (HPH) 和溶剂位移方法 (SDM) 用于粒子形成.
- 在4°C下进行30天的粒子大小分析和稳定性测试.
主要成果:
- γ-oryzanol表现出较差的表面活性特性,导致通过HPH产生不稳定的乳液.
- 由SDM产生的固体分散显示了与Tween 80 (T80) 稳定系统可比的粒子大小.
- 用SDM制造的系统在4°C下保持30天的稳定性,表明具有自我稳定性.
结论:
- 溶剂位移法 (SDM) 促进了自发颗粒的形成,并通过静电排斥防止聚合,展示了g-oryzanol的自我稳定潜力.
- SDM提供了一个可行的途径,用于创建稳定的合体系统与生物活性化合物,如g-oryzanol,消除了对额外的乳化剂的需求.
- 这种方法对封装各种生物活性化合物充满希望,无论它们固有的表面活性特性如何.
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