门诊亲肠道抗生素治疗 (OPAT) 用于支气管切除症的管理
Jacky Tu1, Mohammed Al Harasi1, Michael Pallin1
1Monash Lung, Sleep, Allergy and Immunology, Monash Medical Centre (MMC), Clayton, Melbourne, Australia.
Heliyon
|October 9, 2023
概括
门诊亲肠道抗生素治疗 (OPAT) 是一种安全有效的治疗急性支气管切除症恶化在囊性纤维化和非囊性纤维化患者. 这种方法减少了住院病例,并具有较低的并发症率.
科学领域:
- 肺部病理学 肺部病理学
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 支气管切除症的恶化经常需要住院的静脉注射抗生素治疗.
- 门诊亲肠道抗生素治疗 (OPAT) 提供了家庭治疗的潜在替代方案.
- 家庭护理的OPAT服务越来越容易获得.
研究的目的:
- 评估OPAT在治疗急性支气管切除症恶化的结果.
- 为了比较OPAT在囊性纤维化 (CF) 和非CF支气管切除症患者中的有效性.
- 在这些患者群体中评估OPAT的并发症率和再录取数据.
主要方法:
- 对连续接受OPAT治疗支气管切除症恶化患者的回顾性分析.
- 从2016年到2022年,在澳大利亚大型大都会卫生服务机构中进行的研究.
- 包括CF和非CF患者队列进行比较分析.
主要成果:
- 在非CF患者中发生了51次 (主要是塞夫,9.1天),在CF患者中发生了73次 (双抗生素,16.8天).
- 一个月后,非CF患者的再入院率为9.6%,CF患者为0%.
- 观察到的并发症率较低:非CF组的2%,CF组的7%.
结论:
- OPAT是一种可行且有效的支气管切除症恶化管理策略.
- 这些发现支持OPAT作为选择患者住院的可行替代方案.
- 在不同支气管病因学方面,OPAT表现出良好的安全性和有效性概况.
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