腹腔镜袖子胃切除术后肠道微生物群和细胞因子的变化与认知功能改善有关
Wanjing Chen1, Jiahong Song2, Yunsheng Cheng1
1Department of General Surgery, The Second Affiliated Hospital of Anhui Medical University. No.678 Furong Road, Economic and Technological Development District, Hefei City, Anhui Province, 230601, China.
Heliyon
|October 9, 2023
概括
减肥手术通过改变肠道微生物群和减少炎症来改善认知功能. 这些变化表明肠-大脑轴与肥胖症的认知增强之间存在联系.
科学领域:
- 代谢手术 代谢手术
- 神经科学是一个神经科学.
- 微生物组研究 微生物组研究
背景情况:
- 肥胖与认知障碍有关.
- 减肥手术对认知功能,肠道微生物群和细胞因子的影响尚未完全理解.
研究的目的:
- 研究肠道微生物群,细胞因子和肥胖患者在腹腔镜袖子胃切除术 (LSG) 之前和之后的认知功能之间的关系.
主要方法:
- 40名肥胖患者接受了LSG.
- 人口统计,血清和便样本在手术前和后 (3个月) 收集.
- 用蒙特利尔认知评估 (MoCA) 尺度和记忆测试来评估认知功能.
主要成果:
- LSG导致显著的体重减轻和改善认知功能.
- 肠道微生物群的多样性和丰富性增加,特定族群的变化 (例如,增加了Bacteroidetes,减少了Firmicutes).
- 血IL-1β和TNF-α减少,而IL-4增加. 摩卡分数与细胞因子水平和特定细菌系相关.
结论:
- 肠道微生物群的改变与LSG后的认知改善有积极的相关性.
- 炎症性细胞因子可能会调解肠道-微生物群-大脑轴,影响腹腔外科手术后的认知功能.
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