益格拉努林缺乏症加剧了心肌梗塞后的心脏重塑
Takahiro Sasaki1, Yoshiki Kuse1, Shinsuke Nakamura1
1Molecular Pharmacology, Department of Biofunctional Evaluation Gifu Pharmaceutical University Gifu Japan.
FASEB bioAdvances
|October 9, 2023
概括
益格拉努林 (PGRN) 缺乏会通过促进有害的心脏巨细胞极化和纤维化,使心脏病发作的结果恶化. 了解 PGRNN 的理解
科学领域:
- 心血管生物学 心血管生物学
- 免疫学 免疫学 免疫学
- 再生医学是一种再生医学.
背景情况:
- 心肌梗塞 (MI) 导致不可逆转的心肌细胞死亡和心脏重塑.
- 之前的研究表明,复合原原蛋白 (PGRN) 能预防缺血-再输液损伤.
- 在心脏病发作后心脏重塑中PGRN的具体作用在很大程度上是未知的.
研究的目的:
- 调查PGRN缺乏对心脏重塑和心肌梗塞 (MI) 后的结果的影响.
- 阐明PGRN在调节心脏巨细胞极化和心脏中风后功能的作用.
主要方法:
- 在野生型和PGRN淘汰赛小鼠中诱导了心肌梗塞.
- 进行了组织学,电生理学和蛋白质表达分析.
- 心脏巨细胞亚种群的特征是使用流动细胞计;骨髓衍生巨细胞 (BMDMs) 分析了mRNA水平和细胞容量.
主要成果:
- 在心脏中风后,PGRN表达在心脏中增加,在巨细胞中表达丰富.
- 在PGRN淘汰赛的小鼠中,死亡率增加,心脏纤维化和心律失常.
- 缺少PGRN导致巨细胞极化发生变化,透率增加,心肌梗塞中增强的细胞化.
结论:
- PGRN 缺陷加剧了不良的心脏重塑,并降低了心脏中风后的生存率.
- PGRN在调节心脏巨细胞两极分化方面起着至关重要的作用,对于心脏修复至关重要.
- 这些发现提供了关于巨细胞两极分化和心脏中风后心脏修复启动之间的关系的见解.
更多相关视频
07:58Establishment of a Surgically-induced Model in Mice to Investigate the Protective Role of Progranulin in Osteoarthritis
Published on: February 25, 2014
28.6K
09:29An Experimental Model of Myocardial Infarction for Studying Cardiac Repair and Remodeling in Knockout Mice
Published on: July 14, 2023
833
相关概念视频
Myocarditis I: Introduction
9
Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
9
Pathophysiology of Heart Failure
1.6K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
1.6K
Imbalances in Cardiac Output
1.4K
The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
1.4K
Cardiomyopathy III: Hypertrophic Cardiomyopathy
16
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
16
Heart Failure II: Pathophysiology
14
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
14
Cardiomyopathy IV: Restrictive Cardiomyopathy
12
Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
12
