前肢区域到侧面的下丘脑电路驱动社会攻击性社会攻击性
Fuhai Bai1, Lu Huang1, Jiao Deng2
1Department of Anesthesiology, Xinqiao Hospital, Army Medical University, Chongqing 400037, China.
iScience
|October 9, 2023
概括
研究人员发现,抑制中间前额叶皮质 (mPFC) 中的GABAergic神经元可以抑制攻击性. 激活这些神经元减少了男性的侵略性,并为侵略性配对的环境提供了条件化的位置偏好,突出了控制攻击性行为的关键电路.
科学领域:
- 神经科学是一个神经科学.
- 行为生物学 行为生物学
- 社会行为 社交行为
背景情况:
- 对社会物种来说,控制侵略是至关重要的.
- 中间前额叶皮层 (mPFC) 参与调节侵略性行为.
研究的目的:
- 为了研究GABAergic神经元在mPFC的前临区域 (PL) 在控制男性对男性的侵略中的作用.
- 为了确定参与侵略调节的神经通路.
主要方法:
- 在动物的侵略行为期间的电生理记录.
- 对GABAergic PL神经元进行光遗传学操纵.
- 侧向下丘脑 (LH) 或Rexinergic神经元的化学基因调制.
- 有条件的地方偏好 (CPP) 测试.
主要成果:
- 在侵略期间,mPFC的PL中的GABAergic神经元活动被抑制.
- 对GABAergic PL神经元的激活降低了侵略性和对侵略性配对背景的CPP.
- 抑制GABAergic PL神经元增加了攻击性.
- 发现从PL到LH的GABAergic预测可以调节侵略性.
- 调节LH神经元直接影响了攻击性行为.
结论:
- GABAergic PL-orexinergic LH投射是一个关键的神经电路,用于调节男性之间的侵略行为.
- 针对这个电路提供了潜在的治疗策略来制侵略.
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