脑癌患者急性静脉血栓栓塞:临床过程
Cecilia Becattini1, Michela Giustozzi1, José Portillo2
1Department of Internal, Vascular and Emergency Medicine - Stroke Unit, University of Perugia, Perugia, Italy.
Research and practice in thrombosis and haemostasis
|October 9, 2023
概括
患有脑癌和静脉血栓塞栓症 (VTE) 的患者面临内出血 (ICH) 和大出血的风险更高. 这项研究强调了癌症患者的VTE复发率增加,强调了需要量身定制的治疗策略.
科学领域:
- 医学研究 医学研究
- 在瘤学瘤学.
- 血液学 血液学 血液学
背景情况:
- 脑癌患者经常被排除在静脉血栓塞栓症 (VTE) 治疗研究之外,因为担心内出血 (ICH).
- 有限的数据存在于与VTE治疗相关的风险在活跃的大脑癌症患者.
研究的目的:
- 在患有活跃脑癌的患者中调查ICH,复发性VTE和严重出血的风险.
- 将这些风险与患有活跃非脑癌和没有活跃癌症的患者进行比较.
主要方法:
- 一个多中心的国际队列研究,涉及98,377名VTE患者.
- 患者被分为三个组:活跃的脑癌,活跃的非脑癌和没有活跃的癌症.
- 主要结局是3个月后的ICH,随访主要出血和复发性VTE.
主要成果:
- 与非脑癌 (0.3%,0.2%) 和没有癌症 (0.2%,0.1%) 组相比,活跃的大脑癌症患者的ICH (2.8%) 和致命的ICH (1.3%) 发生率明显更高.
- 在脑癌 (3.7%,3.9%) 和非脑癌 (3.2%,3.4%) 组中,严重出血和复发性静脉瘤的发生率都较高,而非癌症组 (1.5%,1.1%) 则较高.
- 质母细胞瘤显示出数量上更高的ICH,致命的ICH和复发性静脉瘤的风险.
结论:
- 静脉瘤患者的活性脑癌与ICH和致命ICH的风险增加有关.
- 为了确定脑癌患者最佳的VTE治疗策略,进一步的研究是必不可少的.
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