神经病痛:我们所知道的以及我们应该做些什么
1Neuroscience and Mental Health Institute and Department of Pharmacology, University of Alberta, Edmonton, AB, Canada.
Frontiers in pain research (Lausanne, Switzerland)
|October 9, 2023
概括
神经病痛是很难治疗的. 目前的动物模型不能完全捕捉人类的状况,需要更好的模型和个性化治疗,以有效的疼痛管理.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 疼痛研究 疼痛研究
背景情况:
- 神经病痛是由于神经系统损伤或疾病引起的,难以治疗.
- 周围神经损伤触发了施万细胞激活和免疫细胞透,导致持续的神经元过度刺激和感觉错误处理.
- 目前的理解在很大程度上源于动物模型,自20世纪90年代中期以来,研究结果的临床翻译有限.
研究的目的:
- 整合关于神经病痛疼痛机制的多学科研究.
- 突出需要改进动物模型和临床分层来实现个性化疼痛管理.
- 弥合基础科学发现与治疗神经病痛的临床应用之间的知识差距.
主要方法:
- 从免疫学,细胞生物学,电生理学,解剖学,神经学,分子生物学,药理学和行为科学中审查和整合信息.
- 对神经病痛现有动物模型的局限性分析.
- 检查在动物模型和人类患者中更好地评估疼痛的策略.
主要成果:
- 经典的动物模型揭示了关键的疼痛机制,如敏感化,但不充分地代表了各种人类神经病痛状况.
- 性别,伤害类型和物种 (人与动物) 之间的疼痛处理差异阻碍了翻译.
- 基础科学和临床实践的改进对于改善疼痛管理至关重要.
结论:
- 迫切需要新的神经病痛治疗方法.
- 目前的动物模型需要改进,以更好地反映人类疾病的复杂性.
- 基于定量评估和精细模型的个性化治疗方法对于有效的神经病痛管理至关重要.
关键词:
亚洛迪尼亚 (Allodynia) 是一种全气体的现象.背部角 背部角背部根部的性腺体神经损伤的神经损伤神经原性神经炎症是什么神经免疫学 神经免疫学神经炎症是一种神经炎症.神经病变是一种神经病变.更多相关视频
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