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循环微RNA-30a,Beclin1及其与代谢健康/不健康肥胖女性不同变量的关联

Mervat Naguib¹, Mohamed Magdy¹, Omar Ahmed Elsayed Yousef²

¹Diabetes and Endocrinology Unite, Internal Medicine Department, Faculty of Medicine, Cairo University, Cairo, Egypt.

Diabetes, metabolic syndrome and obesity : targets and therapy

|October 9, 2023

概括

微RNA-30a是女性代谢不健康肥胖 (MUO) 的关键指标,与代谢健康肥胖 (MHO) 相比,MUO的水平更高,贝克林1更低. 这一发现突出了microRNA-30a.

科学领域:

内分泌学和新陈代谢学
分子生物学分子生物学
肥胖问题研究研究

背景情况:

肥胖与代谢和心血管疾病有关,需要确定导致代谢障碍的因素.
自与代谢综合征的发病有关.
微RNA-30a调节贝克林1,一个关键的自介质.

研究的目的:

评估在代谢不健康肥胖 (MUO) 和代谢健康肥胖 (MHO) 的女性中循环的microRNA-30a和血清贝克林1水平.
确定微RNA-30a和beclin1与肥胖妇女的临床和代谢变量之间的关联.

主要方法:

涉及MHO (n=34),MUO (n=34) 和非肥胖对照 (n=20) 的妇女的横截面研究.
测量包括人体测量,血压,血糖和脂质概况,尿中的白蛋白与肌素的比例,肝酶 (ALT,AST),血清微RNA-30a (实时PCR) 和血清贝克林1 (ELISA).

主要成果:

与MHO女性相比,MUO女性表现出显著更高的microRNA-30a表达和更低的beclin1水平 (P<0.001).
MUO组年龄较大,TSH,HbA1c,甘油三和ALT (P<0.05) 较高.
在多变量分析 (95% CI 1.317-28.252; P=0.021) 中,MicroRNA-30a与MUO表型独立相关.

结论:

微RNA-30a,贝克林1,年龄,ALT和TSH与MUO表型相关.
微RNA-30a成为肥胖女性代谢综合征最重要的预测因子.

关键词:

贝克林是一个人.代谢综合征代谢综合征这是微RNA-30a.肥胖症肥胖症肥胖症肥胖症

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