在同核蛋白病变中住院的风险和精神病的影响
Capucine Piat1, Aidan F Mullan2, Cole D Stang1
1Mayo Clinic Department of Neurology, Rochester, MN, United States.
Frontiers in aging neuroscience
|October 9, 2023
概括
精神病显著增加了同核蛋白病患者住院的风险. 在研究队列中,抗精神病治疗没有改变这种风险或住院时间.
科学领域:
- 神经学 神经学
- 精神病学是一个精神病学.
- 流行病学 流行病学
背景情况:
- 包括帕金森病和勒维体痴呆症在内的同核蛋白病变与精神病有关.
- 对这些患者的住院风险和抗精神病治疗影响的研究有限.
研究的目的:
- 为了确定精神病症的同核蛋白病患者的住院风险.
- 评估抗精神病治疗对住院和住院时间的影响.
主要方法:
- 使用罗切斯特流行病学项目的事件队列研究 (1991-2010).
- 临床诊断由运动障碍专家确认.
- 对住院数据和精神病患病率的分析.
主要成果:
- 患有精神病的患者住院的风险增加了49% (HR=1.49,p<0.01).
- 抗精神病治疗没有显著影响住院风险 (HR=0.93,p=0.65).
- 患有精神病和没有精神病的患者之间,住院时间没有差异.
结论:
- 精神病在同核蛋白病患者中增加了住院的风险.
- 在这个队列中,抗精神病药物的使用没有影响住院的风险或持续时间.
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