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Updated: Sep 3, 2026

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使用激酶催化生物化来识别PP1c-PPP1R12A基质的PP1c-PPP1R12A基质的识别以识别酸酶基质

Pavithra M Dedigama-Arachchige1, Nuwan P N Acharige1, Xiangmin Zhang2

  • 1Department of Chemistry, Wayne State University, 5101 Cass Ave, Detroit 48202-3489, Michigan, United States.

ACS omega
|October 9, 2023
PubMed
概括

蛋白酶1调节子单元12A (PPP1R12A) 和PP1c形成了一个复杂的调节肌肉收缩和细胞骨. 这项研究确定了AKT1激酶作为一种新型基质,揭示了影响肌肉细胞结构的反循环.

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相关概念视频

Protein Kinases and Phosphatases02:54

Protein Kinases and Phosphatases

Proteins undergo chemical modifications that trigger changes in the charge, structure, and conformation of the proteins. Phosphorylation, acetylation, glycosylation, nitrosylation, ubiquitination, lipidation, methylation, and proteolysis are various protein modifications that regulate protein activity. Such modifications are usually enzyme-driven.
Protein kinases
Many proteins in the cell are regulated by phosphorylation, the addition of a phosphate group. A family of enzymes called kinases...