通过拉曼光谱学对亚齐胺素作为固体剂量的定性和定量分析
Muhammad Shahbaz1, Ayesha Tariq1, Muhammad Irfan Majeed1
1Department of Chemistry, University of Agriculture Faisalabad, Faisalabad 38000, Pakistan.
ACS omega
|October 9, 2023
概括
拉曼光谱有效地量化了在固体剂量形式中的活性药物成分 (API),如阿齐思罗米. 这种技术与多变量分析相结合,为制药分析和质量控制提供了可靠的方法.
科学领域:
- 制药科学 制药科学
- 分析化学 分析化学
- 频谱学是一种光谱学.
背景情况:
- 活性药物成分 (API) 和辅助成分是药物的关键成分,需要精确的识别.
- 拉曼光谱是一种强大的,非破坏性的技术,用于分析固体药物剂量形式.
研究的目的:
- 调查拉曼光谱法对药物配方中阿齐思罗米的定性和定量分析的有效性.
- 评估多变量数据分析技术的性能,包括主要组件分析 (PCA) 和部分最小平方回归 (PLSR),与拉曼光谱学结合.
主要方法:
- 拉曼光谱法被用于从药物配方中获取光谱数据,其中含有不同度和辅助剂的阿齐思罗米.
- 主要组件分析 (PCA) 和部分最小平方回归 (PLSR) 用于数据分析和模型开发.
主要成果:
- 拉曼光谱成功地根据其独特的光谱特征识别和量化了阿齐思罗米.
- 该PLSR模型表现出极好的性能,适合度 (R2) 为0.99,RMSE校准值为0.46,RMSE预测值为2.42.
结论:
- 拉曼光谱,通过多变量分析增强,是一种高效的技术,用于药物配方中的API的定量分析.
- 这种方法为制药品质量控制提供了有价值的工具,可以适应各种药物和配方.
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