量化瘤负担成像MRI的参数,用于预测急性白血病患者的治疗反应
Wenjin Bian1,2, Jianling Zhang1, Qianqian Huang1
1Department of Medical Imaging, Shanxi Medical University, Taiyuan, 030001, Shanxi, China.
Heliyon
|October 9, 2023
概括
标准化脏体积和输入素不连贯运动 (IVIM) 参数可以预测急性白血病 (AL) 的治疗反应. 结合这些脏测量可以提高预测准确性,从而改善患者的治疗结果.
科学领域:
- 放射学和成像学 放射学和成像学
- 在瘤学瘤学.
- 血液学 血液学 血液学
背景情况:
- 治疗急性白血病 (AL) 的反应对患者的治疗结果至关重要.
- 准确预测治疗反应对于优化AL管理至关重要.
- 脏参与AL可以反映瘤负担和影响治疗反应.
研究的目的:
- 评估脏标准化体积和内无干运动 (IVIM) 参数对新诊断的AL治疗反应的预测值.
- 评估脏成像参数与瘤负担的临床生物标志物之间的相关性.
- 用MRI和临床数据确定治疗反应的独立预测因素.
主要方法:
- 在化疗前招募了76名新诊断的AL患者进行腹部IVIM扩散权重MRI.
- 量化脏标准化体积和IVIM参数 (sADC,D,f) 的量化.
- 分析了MRI参数和临床生物标志物之间的相关性,并使用后勤回归和ROC曲线来确定治疗反应的预测因素.
主要成果:
- 在完全缓解 (CR) 和非CR组之间,标准化脏体积,D和f显著不同.
- 标准化体积,D和f被确定为治疗反应的独立预测指标.
- 与单个参数相比,标准化体积,D和f的组合显示出优异的预测性能 (AUC = 0.856).
结论:
- 标准化体积和IVIM参数 (D,f) 对于预测AL治疗反应有价值.
- 结合形态 (标准化体积) 和功能 (IVIM参数) assessments,可以提高预测准确度.
- 脏IVIM参数可以作为AL功能瘤负担的有效指标.
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