一项关于肠道微生物群与骨密度,微观结构和强度之间的关联的两组队列研究
Paul C Okoro1, Eric S Orwoll2, Curtis Huttenhower3,4,5,6
1Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife, Boston, MA, United States.
Frontiers in endocrinology
|October 9, 2023
概括
肠道微生物群影响骨健康. 特定的肠道细菌属,如Akkermansia和DTU089,与骨密度变化有关,这表明肠道细菌和骨新陈代谢之间存在联系.
科学领域:
- 微生物组研究的研究.
- 骨生物学 骨生物学
- 人类生理学 人类生理学
背景情况:
- 肠道微生物群影响炎症和T细胞反应,影响骨代谢.
- 目前对肠道微生物群在人类骨健康中的作用的研究是有限的.
- 在小鼠中,骨质细胞生成和骨损失与肠道微生物组介导的炎症途径有关.
研究的目的:
- 研究通过高分辨率外围定量计算断层扫描 (HR-pQCT) 测量的人体肠道微生物组和骨参数之间的关联.
- 分析来自两个大型人类队伍的数据:弗雷明汉心脏研究 (FHS) 和男性骨质疏松症研究 (MrOS).
主要方法:
- 来自FHS和MrOS参与者的便样本的16S rRNA基因测序.
- 使用DADA2管道和SILVA参考数据库进行分类学赋值的生物信息处理.
- 使用MaAslin2包,控制共变量,对微生物种群丰度和HR-pQCT骨测量之间的关联分析.
主要成果:
- 在FHS中的37个微生物属和MrOS中的4个属之间与骨测量 (FDR ≤0.1) 发现了显著的关联.
- 基因 *DTU089* 在两个队列中显示出独立复制的关联与骨测量.
- 分析结果显示,Akkermansia和DTU089与较低的骨矿物密度相关,而Lachnospiraceae NK4A136组和Faecalibacterium与较高的皮皮层骨密度相关.
- 八个代谢途径,包括histidine,purin和pyrimidine生物合成,在一个元分析中与骨皮层骨的测量有关.
结论:
- 这项研究提供了肠道微生物组组成和人类骨健康之间的联系的证据.
- 特定的细菌属和代谢途径可能在调节骨代谢方面发挥作用.
- 需要进一步的研究来阐明肠道微生物群-骨轴背后的机制.
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