低预处理骨矿物质密度在性别不同的年轻人
Juanita K Hodax1,2, Charles Brady2, Sara DiVall1,2
1Division of Pediatric Endocrinology, Department of Pediatrics, Seattle Children's Hospital, Seattle, Washington, USA.
Transgender health
|October 9, 2023
概括
在治疗前,性别多样化的青少年通常具有低骨矿物质密度 (BMD). 较高的体重指数与更好的骨质量相关,而出生时分配的男性性别与较低的治疗前骨密度相关.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 青少年医学 青少年医学
- 骨健康 骨健康
背景情况:
- 性别不同的青少年在治疗前表现出较低的骨矿物质密度 (BMD).
- 在性别确认治疗期间的骨质量变化是可变的.
- 在这群人群中影响骨质量的因素需要进一步调查.
研究的目的:
- 在性别多样化的年轻人中确定与低骨矿物质密度 (BMD) 相关的因素.
- 在一组性别多样化的青少年中分析治疗前的BMDZ分数.
- 探索BMD,体重指数,维生素D水平和出生时分配的性别之间的关系.
主要方法:
- 64名不同性别患者的回顾性分析 (73%在出生时被分配为男性).
- 评估全身和腰椎骨矿物质密度 (BMD) 的部分总值.Z-scores.
- 统计分析以确定与体重指数,维生素D水平和出生时分配的性别的关联.
主要成果:
- 30%的患者的全身BMDZ分数较低;14%的患者的腰椎BMDZ分数较低.
- 身体质量指数和BMD之间观察到一个积极的关联.
- 没有发现维生素D水平与骨硬化之间存在显著的关联.
- 与之前的研究相比,出生时分配的男性性别与较低的治疗前BMDZ-score相关.
结论:
- 治疗前低骨矿物质密度 (BMD) 在性别多元的青少年中很普遍.
- 体重指数是这个人群中与BMD相关的关键因素.
- 出生时分配的性别会影响治疗前的BMD,这凸显出需要量身定制的监测和干预措施.
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