生物粘合性巨孔水凝用于在现场招募和调节树突细胞
Joonsu Han1, Rimsha Bhatta1, Hua Wang1,2,3,4,5,6,7
1Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801 USA.
Cellular and molecular bioengineering
|October 9, 2023
概括
这项研究介绍了一种用于癌症免疫治疗的新型生物粘合性宏水凝. 这种材料有效地招募和调节免疫细胞,对治疗癌症疫苗和其他应用有希望.
科学领域:
- 生物材料科学 生物材料科学
- 免疫学 免疫学 免疫学
- 癌症研究 癌症研究
背景情况:
- 生物材料对于癌症免疫疗法至关重要,特别是治疗性癌症疫苗.
- 开发具有生物相容性,稳定性和招募像树突细胞 (DCs) 这样的免疫细胞的宏性支架仍然是一个挑战.
研究的目的:
- 开发一种生物粘合性宏水凝,用于in situ免疫细胞的招募和调节.
- 为增强癌症免疫疗法,特别是治疗癌症疫苗创建一个平台.
主要方法:
- 合成和表征生物粘合性巨孔凝水凝.
- 在水凝中加入了颗粒细胞-巨细胞殖民地刺激因子 (GM-CSF) 和瘤细胞外囊泡 (EVs).
- 分析了免疫细胞的招募,DC指向和随后的T细胞反应.
主要成果:
- 开发了一种机械坚固的,生物粘合性巨孔水凝,具有受控的化学释放.
- 在现场成功招募了大量的DC用于抗原处理和呈现.
- 已经证明了对抗原特异性CD8+T细胞反应的潜力.
结论:
- 开发的水凝系统为DC招募和调制提供了一个新的平台.
- 这项技术推进了癌症免疫疗法,包括瘤EV疫苗.
- 材料系统具有药物输送,组织再生和免疫抑制的潜力.
相关概念视频
01:14Adhesion
Adhesion occurs when one type of molecule is attracted to a different molecule. Water exhibits adhesive properties in the presence of polar surfaces, such as glass or cellulose in plants. For instance, when water is poured into a glass, the positively charged hydrogen molecules of water are more attracted to the negatively charged oxygen molecules in the silica than to the oxygen in neighboring water molecules.
Capillary action is a result of water’s adhesive tendencies. When a narrow glass...
Capillary action is a result of water’s adhesive tendencies. When a narrow glass...
00:53Tonicity in Plants
Tonicity describes the capacity of a cell to lose or gain water. It depends on the quantity of solute that does not penetrate the membrane. Tonicity delimits the magnitude and direction of osmosis and results in three possible scenarios that alter the volume of a cell: hypertonicity, hypotonicity, and isotonicity. Due to differences in structure and physiology, tonicity of plant cells is different from that of animal cells in some scenarios.Plants and Hypotonic EnvironmentsUnlike animal cells,...
02:34Water and Mineral Acquisition
Specialized tissues in plant roots have evolved to capture water, minerals, and some ions from the soil. Roots exhibit a variety of branching patterns that facilitate this process. The outermost root cells have specialized structures called root hairs that increase the root surface, thus increasing soil contact. Water can passively cross into roots, as the concentration of water in the soil is higher than that of the root tissue. Minerals, in contrast, are actively transported into root cells.
02:41Responses to Drought and Flooding
Water plays a significant role in the life cycle of plants. However, insufficient or excess of water can be detrimental and pose a serious threat to plants.
01:20Tonicity in Plants
Plant cells maintain appropriate osmotic balance in extreme conditions. For instance, plants in dry environments store water in vacuoles, limit the opening of their stoma, and have thick, waxy cuticles to prevent unnecessary water loss. Some species of plants that live in salty environments store salt in their roots. As a result, water osmosis occurs in the root from the surrounding soil.
Tonicity
Tonicity describes the capacity of a cell to lose or gain water depending on the solute...
Tonicity
Tonicity describes the capacity of a cell to lose or gain water depending on the solute...
01:14Cell Adhesion in Plants
Plants have rigid cell walls that are made up of cell wall polysaccharides that mediate cell-cell adhesion. The primary cell walls of plants consist of two independent and interacting polysaccharide networks: a pectin matrix that embeds the second network comprising cellulose and hemicelluloses.
Pectins are complex heteropolymers mainly composed of negatively-charged α-D-glucopyranosyl uronic acid and some neutral glycosyl residues such as α-L-rhamnopyranose, α-L-arabinofuranose, and...
Pectins are complex heteropolymers mainly composed of negatively-charged α-D-glucopyranosyl uronic acid and some neutral glycosyl residues such as α-L-rhamnopyranose, α-L-arabinofuranose, and...