在磁力机械神经调节过程中阐明机械传导过程,由磁纳米光盘介导
Amanda Gomez1, Nicolas Muzzio1, Ania Dudek1
1Department of Biomedical Engineering and Chemical Engineering, The University of Texas at San Antonio, 1 UTSA Circle, San Antonio, TX 78249 USA.
Cellular and molecular bioengineering
|October 9, 2023
概括
这项研究证明了使用磁盘 (MD) 和交替磁场 (AMF) 激活神经元的磁力机械神经调节. 这些发现突显了通过向Piezo1和TRPC1离子通道进行非侵入性治疗的潜力.
科学领域:
- 神经科学是一个神经科学.
- 生物技术是生物技术.
- 生物物理学的生物物理.
背景情况:
- 对神经信号的非侵入性细胞类型特定操纵对于神经科学研究和神经疾病治疗至关重要.
- 磁纳米技术提供了高空间时空控制的非侵入性神经调节.
- 一个使用微型磁盘 (MD) 和交替磁场 (AMF) 的无线强力诱导神经刺激平台已经开发出来.
研究的目的:
- 研究机械力量在磁力机械神经调节中的作用.
- 了解机械力的转导到分子信号,以优化和翻译磁性神经调节技术.
- 通过MDs和AMFs触发细胞膜受体的机械激活来证明细胞脱极化.
主要方法:
- 微型磁盘 (MD) 的制造和功能化.
- 与MDs共同培养初级皮质神经元,并应用弱交替磁场 (AMF).
- 在AMFs刺激期间记录细胞活动,并利用化学阻碍剂对离子通道.
主要成果:
- 由交替磁场 (AMFs) 触发的目标磁盘 (MDs) 的激活在初级大鼠皮层神经元中唤起了神经元活动.
- 离子通道的化学抑制表明,磁力机械神经调节涉及MDs对Piezo1和TRPC1机械敏感离子通道的激活.
- 磁盘 (MDs) 的尺寸影响了执行机制,细胞膜拉伸和MDs扭矩的应力占主导地位.
结论:
- 磁力机械神经调节显示出治疗应用的巨大潜力.
- 该技术需要微不足道的加热 (ΔT < 0.1 °C) 和弱AMF (< 100 Hz),解决当前治疗开发和临床设备设计的局限性.
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