德克斯梅德托米丁作为心肌保护剂在使用心肺旁路术的儿科心脏手术中:系统性审查
Dian Kesumarini1,2, Yunita Widyastuti3, Cindy E Boom1
1Department of Anesthesia and Intensive Therapy, National Cardiovascular Center Harapan Kita, Jakarta.
Annals of medicine and surgery (2012)
|October 9, 2023
概括
德克斯梅德米丁在保护儿童方面表现有前途.
科学领域:
- 心脏病学 心脏病学
- 麻醉学 麻醉学
- 儿科手术 儿科手术
背景情况:
- 德克斯梅德托米丁因其心脏保护性质而越来越受欢迎.
- 有限的研究存在于其在心肺绕道 (CPB) 的儿科心脏手术中的使用.
研究的目的:
- 系统地审查用CPB进行心脏手术的儿科患者中德克斯梅德托米丁的心脏保护作用.
主要方法:
- 在主要数据库 (MEDLINE,Embase,Cochrane图书馆) 进行了全面的文献搜索.
- 包括在内的试验比较心肌损伤生物标志物在儿科患者接受德克斯梅托米丁与安慰剂或其他麻醉剂在CPB期间.
- 两位审查员评估了研究资格,并提取了数据;使用了Cochrane偏差风险工具.
主要成果:
- 分析了6项涉及419名参与者的试验.
- 三项试验 (n=241) 报告说,用德克斯美德托米丁显著降低了中间蛋白-6 (IL-6) 水平.
- 两项试验 (n=180) 显示了较低水平的心脏 I (cTnI) 和肌动脉基因酶-肌动脉带 (CK-MB) 的水平.
结论:
- 大多数研究表明,德克斯梅德托米丁在绕道术期间有效保护心脏损伤.
- 德克斯梅德托米丁可以降低心脏损伤生物标志物,并改善儿科心脏手术患者的临床结果.
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